8 Result(s)
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Aparna Prasad
Life Sciences
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Article
Open AccessDevelopmental and Injury-induced Changes in DNA Methylation in Regenerative versus Non-regenerative Regions of the Vertebrate Central Nervous System
Because some of its CNS neurons (e.g., retinal ganglion cells after optic nerve crush (ONC)) regenerate axons throughout life, whereas others (e.g., hindbrain neurons after spinal cord injury (SCI)) lose this cap...
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Article
Open AccessComparative gene expression profiling between optic nerve and spinal cord injury in Xenopus laevis reveals a core set of genes inherent in successful regeneration of vertebrate central nervous system axons
The South African claw-toed frog, Xenopus laevis, is uniquely suited for studying differences between regenerative and non-regenerative responses to CNS injury within the same organism, because some CNS neurons (...
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Article
Open AccessVariant detection and the Autism sequencing project
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Article
Comprehensive assessment of array-based platforms and calling algorithms for detection of copy number variants
When embarking on a microarray-based study of genomic copy number variation, what's helpful for navigating the myriad of available array platforms and data analysis approaches? Pinto et al. evaluate six samples f...
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Article
Open AccessA 2cM genome-wide scan of European Holstein cattle affected by classical BSE
Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Polymorphisms that alter the prion p...
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Article
Open AccessA first generation whole genome RH map of the river buffalo with comparison to domestic cattle
The recently constructed river buffalo whole-genome radiation hybrid panel (BBURH5000) has already been used to generate preliminary radiation hybrid (RH) maps for several chromosomes, and buffalo-bovine comparat...
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Article
Open AccessHigh resolution radiation hybrid maps of bovine chromosomes 19 and 29: comparison with the bovine genome sequence assembly
High resolution radiation hybrid (RH) maps can facilitate genome sequence assembly by correctly ordering genes and genetic markers along chromosomes. The objective of the present study was to generate high res...
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Article
Open AccessA second generation radiation hybrid map to aid the assembly of the bovine genome sequence
Several approaches can be used to determine the order of loci on chromosomes and hence develop maps of the genome. However, all map** approaches are prone to errors either arising from technical deficiencies...
