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Article
Open AccessModulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest
Brain injury is a leading cause of morbidity and mortality in patients resuscitated from cardiac arrest. Mitochondrial dysfunction contributes to brain injury following cardiac arrest; therefore, therapies tha...
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Article
Open AccessMitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons
Mitochondrial dynamics and mitophagy are constitutive and complex systems that ensure a healthy mitochondrial network through the segregation and subsequent degradation of damaged mitochondria. Disruption of t...
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Article
Open AccessMachine learning-based classification of mitochondrial morphology in primary neurons and brain
The mitochondrial network continually undergoes events of fission and fusion. Under physiologic conditions, the network is in equilibrium and is characterized by the presence of both elongated and punctate mit...
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Article
Open AccessMitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury
Mitochondria are key regulators of cell fate during disease. They control cell survival via the production of ATP that fuels cellular processes and, conversely, cell death via the induction of apoptosis throug...
