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    A functional genomics approach to the mode of action of apratoxin A

    The cyanobacterial metabolite apratoxin A (1) demonstrates potent cytotoxicity against tumor cell lines by a hitherto unknown mechanism. We have used functional genomics to elucidate the molecular basis for this ...

    Hendrik Luesch, Sumit K Chanda, R Marina Raya, Paul D DeJesus… in Nature Chemical Biology (2006)