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  1. Article

    Open Access

    Individual responsiveness of macrophage migration inhibitory factor predicts long-term cognitive impairment after bacterial meningitis

    Patients with pneumococcal meningitis are at risk for death and neurological sequelae including cognitive impairment. Functional genetic polymorphisms of macrophage migration inhibitory factor (MIF) alleles ha...

    Anne T. Kloek, Mercedes Valls Seron, Ben Schmand in Acta Neuropathologica Communications (2021)

  2. Article

    Open Access

    Complement C5 Contributes to Brain Injury After Subarachnoid Hemorrhage

    Previous studies showed that complement activation is associated with poor functional outcome after aneurysmal subarachnoid hemorrhage (SAH). We investigated whether complement activation is underlying brain i...

    Bart J. van Dijk, Joost C.M. Meijers, Anne T. Kloek in Translational Stroke Research (2020)

  3. Article

    Open Access

    Host genetic variability and pneumococcal disease: a systematic review and meta-analysis

    Pneumonia, sepsis, meningitis, and empyema due to Streptococcus pneumoniae is a major cause of morbidity and mortality. We provide a systemic overview of genetic variants associated with susceptibility, phenotype...

    Anne T. Kloek, Matthijs C. Brouwer, Diederik van de Beek in BMC Medical Genomics (2019)