8 Result(s)

Article

Evaluating the immunologically “cold” tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models

Immune-positron emission tomography (PET) imaging with tracers that target CD8 and granzyme B has shown promise in predicting the therapeutic response following immune checkpoint blockade (ICB) in immunologica...

Yun Lu, Hailey A. Houson, Carlos A. Gallegos, Alessandro Mascioni… in Breast Cancer Research (2024)

Article

Dual anti-HER2/EGFR inhibition synergistically increases therapeutic effects and alters tumor oxygenation in HNSCC

Epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and hypoxia are associated with radioresistance. The goal of this study is to study the synergy of anti-HER2, trastuzum...

Patrick N. Song, Shannon E. Lynch, Chloe T. DeMellier, Ameer Mansur… in Scientific Reports (2024)

Article

Quantitative multiparametric MRI predicts response to neoadjuvant therapy in the community setting

The purpose of this study was to determine whether advanced quantitative magnetic resonance imaging (MRI) can be deployed outside of large, research-oriented academic hospitals and into community care settings...

John Virostko, Anna G. Sorace, Kalina P. Slavkova… in Breast Cancer Research (2021)

Article

Author Correction: Positron emission tomography imaging with ⁸⁹Zr-labeled anti-CD8 cys-diabody reveals CD8⁺ cell infiltration during oncolytic virus therapy in a glioma murine model

Benjamin B. Kasten, Hailey A. Houson, Jennifer M. Coleman… in Scientific Reports (2021)

Article

Positron emission tomography imaging with ⁸⁹Zr-labeled anti-CD8 cys-diabody reveals CD8⁺ cell infiltration during oncolytic virus therapy in a glioma murine model

Determination of treatment response to immunotherapy in glioblastoma multiforme (GBM) is a process which can take months. Detection of CD8⁺ T cell recruitment to the tumor with a noninvasive imaging modality such...

Benjamin B. Kasten, Hailey A. Houson, Jennifer M. Coleman… in Scientific Reports (2021)

Article

CD4 T-cell immune stimulation of HER2 + breast cancer cells alters response to trastuzumab in vitro

The HER2 + tumor immune microenvironment is composed of macrophages, natural killer cells, and tumor infiltrating lymphocytes, which produce pro-inflammatory cytokines. Determining the effect of T-cells on HER...

Patrick N. Song, Ameer Mansur, Kari J. Dugger, Tessa R. Davis… in Cancer Cell International (2020)

Article

Anti-HER2 induced myeloid cell alterations correspond with increasing vascular maturation in a murine model of HER2+ breast cancer

Therapy targeted to the human epidermal growth factor receptor type 2 (HER2) is used in combination with cytotoxic therapy in treatment of HER2+ breast cancer. Trastuzumab, a monoclonal antibody that targets H...

Meghan J. Bloom, Angela M. Jarrett, Todd A. Triplett, Anum K. Syed… in BMC Cancer (2020)

Article

Experimentally-driven mathematical modeling to improve combination targeted and cytotoxic therapy for HER2+ breast cancer

The goal of this study is to experimentally and computationally investigate combination trastuzumab-paclitaxel therapies and identify potential synergistic effects due to sequencing of the therapies with in vitro

Angela M. Jarrett, Alay Shah, Meghan J. Bloom, Matthew T. McKenna… in Scientific Reports (2019)