19 Result(s)
within
Anna Andersson
English
-
Article
Drug inhibition indicates a single-site model of the 5-HT uptake site/antidepressant binding site in rat and human brain
Drug inhibition against [3H]paroxetine binding to rat cortex and human putamen was investigated in saturation experiments. The addition of 5-HT, imipramine, citalopram and clomipramine all produced changes in app...
-
Article
AM404 and VDM 11 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide
AM404 [N-(4-hydroxyphenyl)arachidonylamide] and VDM 11 [(5Z,8Z,11Z,14Z)-N-(4-hydroxy-2-methylphenyl)-5,8,11,14-eicosatetraenamide] are commonly used to prevent the cellular accumulation of the endocannabinoid ana...
-
Article
Open AccessAutomated purification of soluble histidine tagged integrase of Tn21 expressed in E. coli cells in low amounts
-
Article
Open AccessResting CD4+effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function
Previously we described a system whereby human peripheral blood T cells stimulated for 8 days in a cytokine cocktail acquired effector function for contact-dependent induction of proinflammatory cytokines from...
-
Article
Open AccessRecurrent and multiple bladder tumors show conserved expression profiles
Urothelial carcinomas originate from the epithelial cells of the inner lining of the bladder and may appear as single or as multiple synchronous tumors. Patients with urothelial carcinomas frequently show recu...
-
Article
The FLT3 inhibitor PKC412 in combination with cytostatic drugs in vitro in acute myeloid leukemia
An internal tandem duplication of FLT3 (FLT3/ITD) occurs in approximately 25% of newly diagnosed AML. PKC412 inhibits the growth of leukemic cell lines with FLT3 mutations such as the MV4-11. This study evalua...
-
Article
Open AccessGene expression signatures in childhood acute leukemias are largely unique and distinct from those of normal tissues and other malignancies
Childhood leukemia is characterized by the presence of balanced chromosomal translocations or by other structural or numerical chromosomal changes. It is well know that leukemias with specific molecular abnorm...
-
Article
Open AccessDownsizing Treatment with Tyrosine Kinase Inhibitors in Patients with Advanced Gastrointestinal Stromal Tumors Improved Resectability
Gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase KIT. Most GISTs have mutations in the KIT or PDGFRA gene, causing activation of tyrosine kinase. Imatinib, a tyrosine kinase inhibitor ...
-
Article
The genomic landscape of hypodiploid acute lymphoblastic leukemia
Linda Holmfeldt, Lei Wei et al. report whole-genome and exome sequencing of 40 childhood hypodiploid acute lymphoblastic leukemias.
-
Article
Open AccessIdentification of small RNAs in extracellular vesicles from the commensal yeast Malassezia sympodialis
Malassezia is the dominant fungus in the human skin mycobiome and is associated with common skin disorders including atopic eczema (AE)/dermatitis. Recently, it was found that Malassezia sympodialis secretes nano...
-
Article
Open AccessExtracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin
Malassezia sympodialis is a dominant commensal fungi in the human skin mycobiome but is also associated with common skin disorders including atopic eczema (AE). M. sympodialis releases extracellular vesicles, des...
-
Article
Open AccessEvaluating gas chromatography with a halogen-specific detector for the determination of disinfection by-products in drinking water
The occurrence of disinfection by-products (DBPs) in drinking water has become an issue of concern during the past decades. The DBPs pose health risks and are suspected to cause various cancer forms, be genoto...
-
Article
Open AccessAdaptation of the Canine Orthopaedic Index to evaluate chronic elbow osteoarthritis in Swedish dogs
Owner questionnaires may be used to assess osteoarthritis (OA) in dogs. The validated American College of Veterinary Surgeons’ (ACVS) Canine Orthopaedic Index Questionnaire quantifies quality of life in dogs w...
-
Article
Open AccessAuthor Correction: Extracellular nanovesicles released from the commensal yeast Malassezia sympodialis are enriched in allergens and interact with cells in human skin
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
-
Article
Open AccessEpigenetic alterations in skin homing CD4+CLA+ T cells of atopic dermatitis patients
T cells expressing the cutaneous lymphocyte antigen (CLA) mediate pathogenic inflammation in atopic dermatitis (AD). The molecular alterations contributing to their dysregulation remain unclear. With the aim t...
-
Chapter and Conference Paper
Applying and Evaluating the KYKLOS Method
Organizations are dealing with a continuous need to adapt to their dynamic environments by changing their business capabilities. KYKLOS is a recently developed modeling method aiming to provide methodological ...
-
Article
Open AccessStrengthening the policy framework to resolve lax implementation of the Baltic Sea Action Plan for agriculture
In this perspective article, we provide recommendations for strengthening the policy framework for protecting the Baltic Sea from agricultural nutrient pollution. The most striking weakness is the lax implemen...
-
Article
Open AccessHow unnecessarily high abatement costs and unresolved distributional issues undermine nutrient reductions to the Baltic Sea
This paper systematically reviews the literature on how to reduce nutrient emissions to the Baltic Sea cost-effectively and considerations for allocating these costs fairly among countries. The literature show...
-
Article
Open AccessApplication and evaluation of interlinked approaches for modeling changing capabilities
The nature of modern organizations needs to be increasingly adaptive, since they are dealing with a constant demand to respond to stimuli derived from the dynamic environments they operate in. Changing their c...
