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  1. No Access

    Article

    Population Pharmacokinetics and Pharmacodynamics of Carfilzomib in Combination with Rituximab, Ifosfamide, Carboplatin, and Etoposide in Adult Patients with Relapsed/Refractory Diffuse Large B Cell Lymphoma

    In patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL), salvage chemotherapy regimens (e.g., rituximab, ifosfamide, carboplatin, and etoposide, R-ICE) yield poor outcomes. Carfilzomib...

    Lan-Hsi Lin, Mohammad Ghasemi, Sarah M. Burke, Cory K. Mavis… in Targeted Oncology (2023)

  2. Article

    Open Access

    Individualization of Irinotecan Treatment: A Review of Pharmacokinetics, Pharmacodynamics, and Pharmacogenetics

    Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung cancer. Irinotecan therapy is...

    Femke M. de Man, Andrew K. L. Goey, Ron H. N. van Schaik… in Clinical Pharmacokinetics (2018)

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  3. No Access

    Article

    The Effect of St John’s Wort on the Pharmacokinetics of Docetaxel

    St John’s wort (SJW), a herbal antidepressant, is commonly used by cancer patients, and its component hyperforin is a known inducer of the cytochrome P450 (CYP) isoenzyme 3A4. Here, the potential pharmacokinet...

    Andrew K. L. Goey, Irma Meijerman, Hilde Rosing… in Clinical Pharmacokinetics (2014)