4 Result(s)
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Article
Open AccessFunctional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death
Owing to lagging or insufficient neo-angiogenesis, hypoxia is a feature of most solid tumors. Hypoxic tumor regions contribute to resistance against antiproliferative chemotherapeutics, radiotherapy and immuno...
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Article
Open AccessMolecular basis of telaprevir resistance due to V36 and T54 mutations in the NS3-4A protease of the hepatitis C virus
The inhibitor telaprevir (VX-950) of the hepatitis C virus (HCV) protease NS3-4A has been tested in a recent phase 1b clinical trial in patients infected with HCV genotype 1. This trial revealed residue mutati...
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Article
Open AccessGOTax: investigating biological processes and biochemical activities along the taxonomic tree
We describe GOTax, a comparative genomics platform that integrates protein annotation with protein family classification and taxonomy. User-defined sets of proteins, protein families, annotation terms or taxon...
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Article
Open AccessA new measure for functional similarity of gene products based on Gene Ontology
Gene Ontology (GO) is a standard vocabulary of functional terms and allows for coherent annotation of gene products. These annotations provide a basis for new methods that compare gene products regarding their...
