6 Result(s)
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Andreas Gnirke
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessCorrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
Cancer evolution is fueled by epigenetic as well as genetic diversity. In chronic lymphocytic leukemia (CLL), intra-tumoral DNA methylation (DNAme) heterogeneity empowers evolution. Here, to comprehensively st...
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Article
Open AccessGenome-wide tracking of dCas9-methyltransferase footprints
In normal mammalian development cytosine methylation is essential and is directed to specific regions of the genome. Despite notable advances through map** its genome-wide distribution, studying the direct c...
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Article
Open AccessTranscription factor binding dynamics during human ES cell differentiation
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wid...
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Article
Open AccessThe African coelacanth genome provides insights into tetrapod evolution
The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar...
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Article
Open AccessInsights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
Ustilago maydis is an important fungal pathogen of maize, causing corn smut. It is well adapted to its host and proliferates in living plant tissue without inducing a defence response. The genome sequence of U. m...
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Article
Correction: Corrigendum: DNA sequence and analysis of human chromosome 18
Nature 437, 551–555 (2005) doi:10.1038/nature03983 The name of Keith O'Neill was accidentally omitted from the published author list. He is at the first affiliation in the address list.
