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  1. Article

    Open Access

    The modulation of iron metabolism affects the Rhabdomyosarcoma tumor growth in vitro and in vivo

    Rhabdomyosarcoma (RMS) is an aggressive rare neoplasm that derives from mesenchymal cells, which frequently develops resistance to the current therapies and the formation of metastases. Thus, new therapies are...

    Michela Asperti, Luca Cantamessa, Magdalena Gryzik… in Clinical and Experimental Medicine (2023)

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  2. No Access

    Article

    Probing of the reactive center loop region of alpha-1-antitrypsin by mutagenesis predicts new type-2 dysfunctional variants

    Lung disease in alpha-1-antitrypsin deficiency (AATD) mainly results from insufficient control of the serine proteases neutrophil elastase (NE) and proteinase-3 due to reduced plasma levels of alpha-1-antitryp...

    Andrea Denardo, Emna Ben Khlifa, Mattia Bignotti… in Cellular and Molecular Life Sciences (2023)

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    Protocol

    Characterization of Novel Alpha-1-Antitrypsin Coding Variants in a Mammalian Cellular Model

    Advances in genetic screening technologies have considerably accelerated the discovery of rare alpha-1-antitrypsin (AAT) variants. Expression in cellular models is an effective approach to evaluate the pathoge...

    Andrea Denardo, Emna Ben Khlifa, Mattia Bignotti, Annamaria Fra in Alpha-1 Antitrypsin (2024)