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    Article

    Probing of the reactive center loop region of alpha-1-antitrypsin by mutagenesis predicts new type-2 dysfunctional variants

    Lung disease in alpha-1-antitrypsin deficiency (AATD) mainly results from insufficient control of the serine proteases neutrophil elastase (NE) and proteinase-3 due to reduced plasma levels of alpha-1-antitryp...

    Andrea Denardo, Emna Ben Khlifa, Mattia Bignotti… in Cellular and Molecular Life Sciences (2023)