4 Result(s)
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Article
Open AccessOptimizing Column Length and Particle Size in Preparative Batch Chromatography Using Enantiomeric Separations of Omeprazole and Etiracetam as Models: Feasibility of Taguchi Empirical Optimization
The overreaching purpose of this study is to evaluate new approaches for determining the optimal operational and column conditions in chromatography laboratories, i.e., how best to select a packing material of pr...
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Article
Open AccessCombining Chemometric Models with Adsorption Isotherm Measurements to Study Omeprazole in RP-LC
The adsorption of the proton-pump inhibitor omeprazole was investigated using RP-LC with chemometric models combined with adsorption isotherm modelling to study the effect of pH and type of organic modifier (i...
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Article
Evaluation Conditions for SFC of Metoprolol and Related Amino Alcohols on Hypercarb (Porous Graphitic Carbon) with Respect to Structure–Selectivity Relations
Mobile phase chromatographic conditions for the selective separation of metoprolol from related amino alcohols have been evaluated using Hypercarb as support and carbon dioxide with addition of methanol as mob...
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Article
Reversal of Enantiomeric Retention Order by Using a Single N-Derivatized Dipeptide as Chiral Mobile Phase Additive and Porous Graphitised Carbon as Stationary Phase
In this work the three dipeptides, Z-l-alanyl-l-glutaric acid (Z-l-ala-l-glu), Z-l-phenylanyl-l-glutaric acid (Z-l-phe-l-glu) and Z-glycyl-l-glutaric acid (Z-gly-l-glu) were tested as chiral counter ions for enan...
