6 Result(s)
within
Ana B. Pavel
English
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Article
Open AccessIntegrating mutation and gene expression cross-sectional data to infer cancer progression
A major problem in identifying the best therapeutic targets for cancer is the molecular heterogeneity of the disease. Cancer is often caused by an accumulation of mutations which produce irreversible damage to...
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Article
Open AccessIntegrative modeling of multi-omics data to identify cancer drivers and infer patient-specific gene activity
High throughput technologies have been used to profile genes in multiple different dimensions, such as genetic variation, copy number, gene and protein expression, epigenetics, metabolomics. Computational anal...
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Article
Open AccessGenetic load makes cancer cells more sensitive to common drugs: evidence from Cancer Cell Line Encyclopedia
Genetic alterations initiate tumors and enable the evolution of drug resistance. The pro-cancer view of mutations is however incomplete, and several studies show that mutational load can reduce tumor fitness. ...
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Article
Apremilast and narrowband ultraviolet B combination therapy suppresses Th17 axis and promotes melanogenesis in vitiligo skin: a randomized, split-body, pilot study in skin types IV–VI
Improved repigmentation of generalized vitiligo in skin types IV–VI has been reported in clinical response to combined therapy with apremilast and narrowband (NB)-UVB; however, tissue responses to combined the...
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Article
Secukinumab responses vary across the spectrum of congenital ichthyosis in adults
Treatment of congenital ichthyoses primarily focuses on reversing skin scaling and is not pathogenesis based. Recent studies showed Th17 immune skewing, as in psoriasis, across the spectrum of ichthyosis, sugg...
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Article
Open AccessIntegrative genetic and genomic networks identify microRNA associated with COPD and ILD
Chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD) are clinically and molecularly heterogeneous diseases. We utilized clustering and integrative network analyses to elucidate role...
