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  1. No Access

    Article

    Protective role for netrin-1 during diabetic nephropathy

    Recent studies implicate neuronal guidance molecules in the orchestration of inflammatory events. For example, previous studies demonstrate a functional role for netrin-1 in attenuating acute kidney injury. He...

    Eunyoung Tak, Douglas Ridyard, Alexander Badulak… in Journal of Molecular Medicine (2013)

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    Article

    Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

    Inflammatory lesions, ischemic tissues, or solid tumors are characterized by the occurrence of severe tissue hypoxia within the diseased tissue. Subsequent stabilization of hypoxia-inducible transcription fact...

    Jens M. Poth, Kelley Brodsky, Heidi Ehrentraut… in Journal of Molecular Medicine (2013)

  3. No Access

    Article

    Detrimental effects of adenosine signaling in sickle cell disease

    Yu** Zhang et al. discovered that the concentration of adenosine in the blood is increased both in a mouse model of sickle cell disease and in humans with this disease. Adenosine seems to have a pathological rol...

    Yu** Zhang, Yingbo Dai, Jiaming Wen, Weiru Zhang, Almut Grenz, Hong Sun… in Nature Medicine (2011)

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    Reference Work Entry In depth

    Hypoxia

    Holger K. Eltzschig, Almut Grenz in Encyclopedia of Molecular Mechanisms of Disease (2009)