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Article
Self-focused attention in panic disorder
Self-focused attention refers to attention consciously directed toward the self. Although cognitive models of panic posit the importance of attending to internal sensations and the role of this self-focus in t...
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Article
cDNA microarray analysis of genes associated with ERBB2 (HER2/neu) overexpression in human mammary luminal epithelial cells
To investigate changes in gene expression associated with ERBB2, expression profiling of immortalized human mammary luminal epithelial cells and variants expressing a moderate and high level of ERBB2 has been car...
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Article
DNA methylation of polycomb group target genes in cores taken from breast cancer centre and periphery
We previously demonstrated that methylation of neugogenic differentiation 1 (NEUROD1) gene, a polycomb group target (PCGT) gene is a predictor of response to neoadjuvant chemotherapy in breast cancer. Here, we ad...
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Chapter and Conference Paper
Comparative Feedback in the Street: Exposing Residential Energy Consumption on House Façades
This study investigates the impact of revealing the changes in daily residential energy consumption of individual households on their respective house faç ades. While energy feedback devices are now commercial...
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Article
Open AccessEpigenetic variability in cells of normal cytology is associated with the risk of future morphological transformation
Recently, it has been proposed that epigenetic variation may contribute to the risk of complex genetic diseases like cancer. We aimed to demonstrate that epigenetic changes in normal cells, collected years in ...
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Article
Open AccessA BRCA1-mutation associated DNA methylation signature in blood cells predicts sporadic breast cancer incidence and survival
BRCA1 mutation carriers have an 85% risk of develo** breast cancer but the risk of develo** non-hereditary breast cancer is difficult to assess. Our objective is to test whether a DNA methylation (DNAme) sign...
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Article
Open AccessAn integrative pan-cancer-wide analysis of epigenetic enzymes reveals universal patterns of epigenomic deregulation in cancer
One of the most important recent findings in cancer genomics is the identification of novel driver mutations which often target genes that regulate genome-wide chromatin and DNA methylation marks. Little is kn...
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Article
Open AccessHOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer
Understanding carboplatin resistance in ovarian cancer is critical for the improvement of patients’ lives. Multipotent mesenchymal stem cells or an aggravated epithelial to mesenchymal transition phenotype of ...
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Article
Open AccessThe integrative epigenomic-transcriptomic landscape of ER positive breast cancer
While recent integrative analyses of copy number and gene expression data in breast cancer have revealed a complex molecular landscape with multiple subtypes and many oncogenic/tumour suppressor driver events,...
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Article
Open AccessA donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative treatment for many hematological conditions. Acute graft-versus-host disease (aGVHD) is a prevalent immune-mediated complication followin...
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Chapter and Conference Paper
Can You Read the Sign? Consumers’ Utilization of Water Use Information and Price as Sign Cues
The purpose of our study was to employ a retail garden center context and the use of eye-tracking technology to analyze the relationship between attention to signage information cues and likelihood to buy (LTB...
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Article
Open AccessDNA methylation outliers in normal breast tissue identify field defects that are enriched in cancer
Identifying molecular alterations in normal tissue adjacent to cancer is important for understanding cancer aetiology and designing preventive measures. Here we analyse the DNA methylome of 569 breast tissue s...
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Article
Open AccessStochastic epigenetic outliers can define field defects in cancer
There is growing evidence that DNA methylation alterations may contribute to carcinogenesis. Recent data also suggest that DNA methylation field defects in normal pre-neoplastic tissue represent infrequent sto...
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Article
Open AccessEpigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution
The exact timing and contribution of epigenetic reprogramming to carcinogenesis are unclear. Women harbouring BRCA1/2 mutations demonstrate a 30–40-fold increased risk of high-grade serous extra-uterine Müllerian...
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Article
Open AccessErratum to: The integrative epigenomic-transcriptomic landscape of ER positive breast cancer
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Article
Open AccessMethylation patterns in serum DNA for early identification of disseminated breast cancer
Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We ...
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Article
Open AccessThe potential of circulating tumor DNA methylation analysis for the early detection and management of ovarian cancer
Despite a myriad of attempts in the last three decades to diagnose ovarian cancer (OC) earlier, this clinical aim still remains a significant challenge. Aberrant methylation patterns of linked CpGs analyzed in...
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Article
Epigenome-based cancer risk prediction: rationale, opportunities and challenges
Epigenetic misprogramming is an essential component of cancer development.
DNA methylation-based risk-predi...
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Article
Open AccessDNA methylation signatures to predict the cervicovaginal microbiome status
The composition of the microbiome plays an important role in human health and disease. Whether there is a direct association between the cervicovaginal microbiome and the host’s epigenome is largely unexplored.
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Article
Open AccessThe WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples
Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the ...
