-
Article
Prediction of fragility fractures in men with prostate cancer under androgen deprivation therapy: the importance of a multidisciplinary approach using a mini-invasive diagnostic tool
Bone fragility in men who are treated with androgen deprivation therapy (ADT) has a complex pathophysiology that differs from that of primary and post-menopausal osteoporosis. Fracture risk assessment based on...
-
Article
Open AccessOptimising Radioligand Therapy for Patients with Gastro-Entero-Pancreatic Neuroendocrine Tumours: Expert Opinion from an Italian Multidisciplinary Group
Radioligand therapy (RLT) with lutetium (177Lu) oxodotreotide is an approved therapy in combination with somatostatin analogues (SSAs) for patients with advanced, well-differentiated G1–G2, gastro-entero-pancreat...
-
Article
Open AccessTerapia del carcinoma corticosurrenalico dopo fallimento del mitotane
Il mitotane rappresenta l’unico farmaco approvato con specifica attività citotossica sulle cellule della corticale del surrene. Viene utilizzato nella terapia medica del carcinoma corticosurrenalico (ACC) nel ...
-
Article
The diagnostic and prognostic role of combined [18F]FDG and [68Ga]-DOTA-peptides PET/CT in primary pulmonary carcinoids: a multicentric experience
In the present retrospective multicentric study, we combined [68Ga]-DOTA-peptides and [18F]FDG-PET/CT findings aiming to investigate their capability to differentiate typical (TC) and atypical pulmonary carcinoid...
-
Article
Open AccessMaintenance of androgen deprivation therapy or testosterone supplementation in the management of castration-resistant prostate cancer: that is the question
Whether or not androgen receptor (AR) axis could still be targetable in castration resistant prostate cancer (CRPC) patients with disease progression to next generation hormonal agents (NGHAs) is a controversi...
-
Article
Open AccessSupportive therapies in patients with advanced adrenocortical carcinoma submitted to standard EDP-M regimen
The management of patients with advanced/metastatic adrenocortical carcinoma (ACC) is challenging, EDP-M (etoposide, doxorubicin, cisplatin combined with mitotane) is the standard regimen. However, it is quite...
-
Article
Eighth International Adrenal Cancer Symposium Brescia, Italy, September 30 to October 1–2, 2021
-
Article
Open AccessFGF/FGFR signaling in adrenocortical development and tumorigenesis: novel potential therapeutic targets in adrenocortical carcinoma
FGF/FGFR signaling regulates embryogenesis, angiogenesis, tissue homeostasis and wound repair by modulating proliferation, differentiation, survival, migration and metabolism of target cells. Understandably, c...
-
Article
Open AccessDifferent management of adrenocortical carcinoma in children compared to adults: is it time to share guidelines?
Pediatric and adult adrenocortical carcinomas differ in many respects but treatment is often similar in both age groups. The Journal of Clinical Oncology recently published the results of a risk-stratified single...
-
Article
Frequency and outcome of SARS-CoV-2 infection in patients with adrenocortical carcinoma followed at a reference center in Italy
-
Article
Maintenance everolimus beyond progression in pancreatic NET to control insulinoma syndrome
-
Chapter
Cancer of the Thyroid
Thyroid cancers are the most frequent endocrine neoplasms whose incidence is globally increasing. Thyroid carcinomas basically derived from follicular (papillary, follicular, anaplastic and poorly differentiat...
-
Chapter
Cancer of the Adrenal Gland
The embryology and physiology of the adrenal gland is complex, and two different tumors may arise according to whether the cell transformation occurs in the cortex or medulla. Most of these tumors are benign, ...
-
Article
Should everolimus be stopped after radiological progression in metastatic insulinoma? A “cons” point of view
Insulinoma is a rare pancreatic neuroendocrine tumor (pNET) potentially associated with severe hypoglycaemic crisis. The great majority of these tumors are benign. In patients with metastatic malignant insulin...
-
Article
Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Outcomes with Nivolumab in Pretreated Non-Small Cell Lung Cancer (NSCLC): A Large Retrospective Multicenter Study
Immune checkpoint inhibitors have provided substantial benefit in non-small cell lung cancer (NSCLC) with unprecedented results in terms of survival. However, the identification of reliable predictive biomarke...
-
Article
Antineoplastic activity of artemisinin in adrenocortical carcinoma
-
Article
Abiraterone and prednisone therapy may cause severe hypoglycemia when administered to prostate cancer patients with type 2 diabetes receiving glucose-lowering agents
-
Article
In vitro antitumor activity of progesterone in human adrenocortical carcinoma
The management of patients with adrenocortical carcinoma (ACC) is challenging. As mitotane and chemotherapy show limited efficacy, there is an urgent need to develop therapeutic approaches. The aim of this stu...
-
Article
Adding metyrapone to chemotherapy plus mitotane for Cushing’s syndrome due to advanced adrenocortical carcinoma
-
Article
Palbociclib inhibits proliferation of human adrenocortical tumor cells