9 Result(s)
within
Alfonso Jaramillo
English
Computational Biology/Bioinformatics
Systems Biology
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Article
Open AccessAutomated design of bacterial genome sequences
Organisms have evolved ways of regulating transcription to better adapt to varying environments. Could the current functional genomics data and models support the possibility of engineering a genome with compl...
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Article
Pushing the limits of automatic computational protein design: design, expression, and characterization of a large synthetic protein based on a fungal laccase scaffold
The de novo engineering of new proteins will allow the design of complex systems in synthetic biology. But the design of large proteins is very challenging due to the large combinatorial sequence space to be e...
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Article
Synthetic biology gains momentum in Europe
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Article
Open AccessRobust dynamical pattern formation from a multifunctional minimal genetic circuit
A practical problem during the analysis of natural networks is their complexity, thus the use of synthetic circuits would allow to unveil the natural mechanisms of operation. Autocatalytic gene regulatory netw...
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Article
Open AccessPROTDES: CHARMM toolbox for computational protein design
We present an open-source software able to automatically mutate any residue positions and find the best aminoacids in an arbitrary protein structure without requiring pairwise approximations. Our software, PRO...
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Article
Open AccessAsmparts: assembly of biological model parts
We propose a new computational tool to produce models of biological systems by assembling models from biological parts. Our software not only takes advantage of modularity, but it also enforces standardisation...
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Article
Open AccessComputational design of digital and memory biological devices
The use of combinatorial optimization techniques with computational design allows the development of automated methods to design biological systems. Automatic design integrates design principles in an unsuperv...
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Article
Open AccessComputational design of proteins with new functions
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Article
Open AccessECOLITASTER: cellular biosensor
