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  1. Article

    Open Access

    T7 phage-assisted evolution of riboswitches using error-prone replication and dual selection

    Leveraging riboswitches, non-coding mRNA fragments pivotal to gene regulation, poses a challenge in effectively selecting and enriching these functional genetic sensors, which can toggle between ON and OFF sta...

    Eduardo Goicoechea Serrano, Carlos Blázquez-Bondia, Alfonso Jaramillo in Scientific Reports (2024)

  2. Article

    Open Access

    Engineering orthogonal dual transcription factors for multi-input synthetic promoters

    Synthetic biology has seen an explosive growth in the capability of engineering artificial gene circuits from transcription factors (TFs), particularly in bacteria. However, most artificial networks still empl...

    Andreas K. Brödel, Alfonso Jaramillo, Mark Isalan in Nature Communications (2016)