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Open AccessBedside analysis of the sublingual microvascular glycocalyx in the emergency room and intensive care unit – the GlycoNurse study
Deterioration of the endothelial glycocalyx (eGC), a protective carbohydrate-rich layer lining the luminal surface of the endothelium, plays a key role in vascular barrier dysfunction and eventually organ-fail...
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Open AccessAssociation of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis
The endothelial glycocalyx (eGC) covers the luminal surface of the vascular endothelium and plays an important protective role in systemic inflammatory states and particularly in sepsis. Its breakdown leads to...
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Article
Open AccessOptical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study
Microcirculatory disorders are crucial in pathophysiology of organ dysfunction in critical illness. Evaluation of sublingual microcirculation is not routinely conducted in daily practice due to time-consuming ...
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Open AccessAuthor Correction: Optical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessMicrovascular dysfunction in COVID-19: the MYSTIC study
Pre-clinical and autopsy studies have fueled the hypothesis that a dysregulated vascular endothelium might play a central role in the pathogenesis of ARDS and multi-organ failure in COVID-19.
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Open AccessIdentification of novel sublingual parameters to analyze and diagnose microvascular dysfunction in sepsis: the NOSTRADAMUS study
The availability of handheld, noninvasive sublingual video-microscopes allows for visualization of the microcirculation in critically ill patients. Recent studies demonstrate that reduced numbers of blood-perf...
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Open AccessIdentification and validation of objective triggers for initiation of resuscitation management of acutely ill non-trauma patients: the INITIATE IRON MAN study
While there are clear national resuscitation room admission guidelines for major trauma patients, there are no comparable alarm criteria for critically ill nontrauma (CINT) patients in the emergency department...
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Open AccessSafety and efficacy of the Seraph® 100 Microbind® Affinity Blood Filter to remove bacteria from the blood stream: results of the first in human study
Bacterial burden as well as duration of bacteremia influence the outcome of patients with bloodstream infections. Promptly decreasing bacterial load in the blood by using extracorporeal devices in addition to ...
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Article
Open AccessMicrovascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study
Although coronavirus disease 2019 (COVID-19) and bacterial sepsis are distinct conditions, both are known to trigger endothelial dysfunction with corresponding microcirculatory impairment. The purpose of this ...
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Open AccessPersistent capillary rarefication in long COVID syndrome
Recent studies have highlighted Coronavirus disease 2019 (COVID-19) as a multisystemic vascular disease. Up to 60% of the patients suffer from long-term sequelae and persistent symptoms even 6 months after the...
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Article
Alarmierungskriterien für den nichttraumatologischen Schockraum – erstes Resümee nach Einführung definitiver Kriterien (V2iSiOn-Kriterien) in Münster
Alarmierungskriterien für die Schockraumanmeldung gab es bis vor Kurzem ausschließlich für Traumapatient:innen. Sie basierten lange Zeit hauptsächlich auf Verletzungsmustern und Unfallmechanismen. Vitalparamet...
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Open AccessEignung des Manchester Triage System zur Weiterleitung nichttraumatologischer Notfallpatienten mit geringer Fallschwere in die kassenärztliche Notfallversorgung: Ergebnisse einer holistischen Kohortenstudie
Zur optimalen Disposition von Selbstvorstellern mit geringer Fallschwere wurde die Einrichtung von integrierten Notfallzentren (INZ) vorgeschlagen. Da jedoch validierte Instrumente zur gezielten Patientenlenku...
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Open Access„Emergency critical care“ in der Notaufnahme. Literaturübersicht und aktuelle Konzepte
Bis zu 10 % aller Notfallpatienten sind intensiv- oder überwachungspflichtig – Tendenz steigend. Im klinischen Alltag können jedoch nur wenige dieser Fälle unmittelbar auf eine Intensiv- oder Überwachungsstati...
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Open AccessInterleukin-6 drives endothelial glycocalyx damage in COVID-19 and bacterial sepsis
Damage of the endothelial glycocalyx (eGC) plays a central role in the development of vascular hyperpermeability and organ damage during systemic inflammation. However, the specific signalling pathways for eGC...
