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Article
Open AccessMaternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study
Mounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examin...
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Article
Open AccessEvaluating the consistency of gene sets used in the analysis of bacterial gene expression data
Statistical analyses of whole genome expression data require functional information about genes in order to yield meaningful biological conclusions. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and G...
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Article
Open AccessEvaluating methods for combining rare variant data in pathway-based tests of genetic association
Analyzing sets of genes in genome-wide association studies is a relatively new approach that aims to capitalize on biological knowledge about the interactions of genes in biological pathways. This approach, ca...
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Article
Open AccessEvaluating methods for the analysis of rare variants in sequence data
A number of rare variant statistical methods have been proposed for analysis of the impending wave of next-generation sequencing data. To date, there are few direct comparisons of these methods on real sequenc...