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  1. Article

    Open Access

    Prediction of exposure-driven myelotoxicity of continuous infusion 5-fluorouracil by a semi-physiological pharmacokinetic–pharmacodynamic model in gastrointestinal cancer patients

    To describe 5-fluorouracil (5FU) pharmacokinetics, myelotoxicity and respective covariates using a simultaneous nonlinear mixed effect modelling approach.

    Usman Arshad, Su-arpa Ploylearmsaeng… in Cancer Chemotherapy and Pharmacology (2020)

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  2. Article

    Open Access

    Development of OXY111A, a novel hypoxia-modifier as a potential antitumor agent in patients with hepato-pancreato-biliary neoplasms - Protocol of a first Ib/IIa clinical trial

    Solid tumors, such as hepato-pancreato-biliary cancer, develop tumor hypoxia with tumor growth. Despite advances in surgery, a majority of these patients are in an unresectable condition. At this stage standar...

    Perparim Limani, Michael Linecker, Philipp Kron, Panagiotis Samaras… in BMC Cancer (2016)

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  3. No Access

    Article

    Impact of variable CYP genotypes on breast cancer relapse in patients undergoing adjuvant tamoxifen therapy

    Tamoxifen is frequently used for the treatment of hormone receptor positive breast cancer (BC). Mainly CYP2D6 is responsible for the transformation to therapeutically active metabolites, but CYP2C19, CYP2C9 a...

    Jessica Mwinyi, Kerstin Vokinger, Alexander Jetter… in Cancer Chemotherapy and Pharmacology (2014)