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Article
Open AccessScreening of global microbiomes implies ecological boundaries impacting the distribution and dissemination of clinically relevant antimicrobial resistance genes
Understanding the myriad pathways by which antimicrobial-resistance genes (ARGs) spread across biomes is necessary to counteract the global menace of antimicrobial resistance. We screened 17939 assembled metag...
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Article
Open AccessEstimating the quality of eukaryotic genomes recovered from metagenomic analysis with EukCC
Microbial eukaryotes constitute a significant fraction of biodiversity and have recently gained more attention, but the recovery of high-quality metagenomic assembled eukaryotic genomes is limited by the curre...
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Article
Open AccessMicrobial community drivers of PK/NRP gene diversity in selected global soils
The emergence of antibiotic-resistant pathogens has created an urgent need for novel antimicrobial treatments. Advances in next-generation sequencing have opened new frontiers for discovery programmes for natu...
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Article
Open AccessA new genomic blueprint of the human gut microbiota
The composition of the human gut microbiota is linked to health and disease, but knowledge of individual microbial species is needed to decipher their biological roles. Despite extensive culturing and sequenci...
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Article
Open AccessMicrobial abundance, activity and population genomic profiling with mOTUs2
Metagenomic sequencing has greatly improved our ability to profile the composition of environmental and host-associated microbial communities. However, the dependency of most methods on reference genomes, whic...
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Article
Open AccessA human gut bacterial genome and culture collection for improved metagenomic analyses
Understanding gut microbiome functions requires cultivated bacteria for experimental validation and reference bacterial genome sequences to interpret metagenome datasets and guide functional analyses. We prese...
