3 Result(s)
within
Albert Escobedo
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessThe energetic and allosteric landscape for KRAS inhibition
Thousands of proteins have been validated genetically as therapeutic targets for human diseases1. However, very few have been successfully targeted, and many are considered ‘undruggable’. This is particularly tru...
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Article
Open AccessA glutamine-based single α-helix scaffold to target globular proteins
The binding of intrinsically disordered proteins to globular ones can require the folding of motifs into α-helices. These interactions offer opportunities for therapeutic intervention but their modulation with...
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Article
Open AccessSide chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor
Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific threshol...
