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  1. Article

    Open Access

    Differential annotation of converted metabolites (DAC-Met): Exploration of Maoto (Ma-huang-tang)-derived metabolites in plasma using high-resolution mass spectrometry

    Traditional herbal medicine (THM) contains a vast number of natural compounds with varying degrees of pharmacological activity. To elucidate the mode of action, comprehensive metabolite profiling in the plasma...

    Katsuya Ohbuchi, Nozomu Sakurai, Hiroyuki Kitagawa, Masaru Sato… in Metabolomics (2020)

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  2. Article

    Open Access

    Three divisions of the mouse caudal striatum differ in the proportions of dopamine D1 and D2 receptor-expressing cells, distribution of dopaminergic axons, and composition of cholinergic and GABAergic interneurons

    The greater part of the striatum is composed of striosomes and matrix compartments, but we recently demonstrated the presence of a region that has a distinct structural organization in the ventral half of the ...

    Yuta Miyamoto, Issei Nagayoshi, Akinori Nishi… in Brain Structure and Function (2019)

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  3. Article

    Open Access

    Striosome-based map of the mouse striatum that is conformable to both cortical afferent topography and uneven distributions of dopamine D1 and D2 receptor-expressing cells

    The striatum is critically involved in execution of appropriate behaviors, but its internal structures remain unmapped due to its unique structural organization, leading to ambiguity when interpreting heteroge...

    Yuta Miyamoto, Sachiko Katayama, Naoki Shigematsu… in Brain Structure and Function (2018)

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  4. No Access

    Article

    Effects of Geissoschizine Methyl Ether, an Indole Alkaloid in Uncaria Hook, a Constituent of Yokukansan, on Human Recombinant Serotonin7 Receptor

    Effects of seven alkaloids, geissoschizine methyl ether (GM), hirsutine, hirsuteine, rhynchophylline, isorhynchophylline, corynoxeine and isocorynoxeine, in Uncaria hook, a constituent of the kampo medicine yo...

    Toshiyuki Ueki, Akinori Nishi, Sachiko Imamura… in Cellular and Molecular Neurobiology (2013)

  5. No Access

    Article

    The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan

    Geissoschizine methyl ether (GM) in Uncaria hook, a galenical constituent of yokukansan is thought to be one of active components in the psychotropic effect of yokukansan, a traditional Japanese medicine (kampo m...

    Sachiko Imamura, Masahiro Tabuchi, Hirotaka Kushida… in Cellular and Molecular Neurobiology (2011)

  6. Article

    Open Access

    QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains

    The activity of mice in their home cage is influenced greatly by the cycle of light and dark. In addition, home-cage activity shows remarkable time-dependent changes that result in a prominent temporal pattern...

    Akinori Nishi, Ayako Ishii, Aki Takahashi, Toshihiko Shiroishi… in Mammalian Genome (2010)

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  7. No Access

    Article

    Sulfation patterns of glycosaminoglycans encode molecular recognition and activity

    Cristal I Gama, Sarah E Tully, Naoki Sotogaku, Peter M Clark… in Nature Chemical Biology (2006)