5 Result(s)
within
Ajay Ravindranathan
English
Pathology
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Article
Open Access“De novo replication repair deficient glioblastoma, IDH-wildtype” is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade
Glioblastoma is a clinically and molecularly heterogeneous disease, and new predictive biomarkers are needed to identify those patients most likely to respond to specific treatments. Through prospective genomi...
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Article
Open AccessSomatic mosaic SOX10 indel mutations underlie a form of segmental schwannomatosis
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Article
Open AccessMultiplatform molecular analyses refine classification of gliomas arising in patients with neurofibromatosis type 1
Gliomas arising in the setting of neurofibromatosis type 1 (NF1) are heterogeneous, occurring from childhood through adulthood, can be histologically low-grade or high-grade, and follow an indolent or aggressi...
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Article
Open AccessEWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma
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Article
Pediatric bithalamic gliomas have a distinct epigenetic signature and frequent EGFR exon 20 insertions resulting in potential sensitivity to targeted kinase inhibition
Brain tumors are the most common solid tumors of childhood, and the genetic drivers and optimal therapeutic strategies for many of the different subtypes remain unknown. Here, we identify that bithalamic gliom...
