3 Result(s)
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Article
Open AccessThe soluble epoxide hydrolase inhibitor TPPU improves comorbidity of chronic pain and depression via the AHR and TSPO signaling
Patients suffering from chronic pain often also exhibit depression symptoms. Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory cytokines. However, whether inhibiting sEH sign...
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Article
Open AccessMolecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites
Although the robust antidepressant effects of the N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine in patients with treatment-resistant depression are beyond doubt, the precise molecular and cellular mec...
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Article
Open AccessKey role of gut microbiota in anhedonia-like phenotype in rodents with neuropathic pain
Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which is a core symptom of depression. Accumulating studies suggest that gut microbiota may play a role in depression via gu...
