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Article
Radiomics-Based Predictive Nomogram for Assessing the Risk of Intracranial Aneurysms
Aneurysm wall enhancement (AWE) has the potential to be used as an imaging biomarker for the risk stratification of intracranial aneurysms (IAs). Radiomics provides a refined approach to quantify and further c...
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Article
Decoding Molecular Mechanisms Underlying Outcomes After Ischemic Stroke Thrombectomy by RNA Sequencing of Retrieved Clots
Transcriptomic profiling has emerged as a powerful tool for exploring the molecular landscape of ischemic stroke clots and providing insights into the pathophysiological mechanisms underlying stroke progressio...
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Article
MicroCT and Histological Analysis of Clot Composition in Acute Ischemic Stroke
Assessing clot composition on prethrombectomy computed tomography (CT) imaging may help in stroke treatment planning. In this study we seek to use microCT imaging of fabricated blood clots to understand the re...
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Article
Open AccessFirst Experience of Treatment of Multiple Shrapnel Traumatic Pseudoaneurysms During the War in Ukraine Using Tegus Telemedical System
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Article
Automated ASPECTS calculation may equal the performance of experienced clinicians: a machine learning study based on a large cohort
The Alberta Stroke Program Early CT Score (ASPECTS) is a semi-quantitative method to evaluate the severity of early ischemic change on non-contrast computed tomography (NCCT) in patients with acute ischemic st...
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Article
Cerebral Fractional Flow Reserve for Functional Evaluation of Intracranial Atherosclerotic Stenosis
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Article
Histologically interpretable clot radiomic features predict treatment outcomes of mechanical thrombectomy for ischemic stroke
Radiomics features (RFs) extracted from CT images may provide valuable information on the biological structure of ischemic stroke blood clots and mechanical thrombectomy outcome. Here, we aimed to identify RFs...
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Article
Profiling of Circulating Gene Expression Reveals Molecular Signatures Associated with Intracranial Aneurysm Rupture Risk
Following detection, rupture risk assessment for intracranial aneurysms (IAs) is critical. Towards molecular prognostics, we hypothesized that circulating blood RNA expression profiles are associated with IA r...
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Article
Meta-analysis of overall survival and postoperative neurologic deficits after resection or biopsy of butterfly glioblastoma
Butterfly glioblastoma (bGBM) is a grade 4 glioma with a poor prognosis. Surgical treatment of these cancers has been reviewed in the literature with some recent studies supporting resection as a safe and effe...
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Article
The association between hemodynamics and wall characteristics in human intracranial aneurysms: a review
Hemodynamics plays a key role in the natural history of intracranial aneurysms (IAs). However, studies exploring the association between aneurysmal hemodynamics and the biological and mechanical characteristic...
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Article
RNA Sequencing Data from Human Intracranial Aneurysm Tissue Reveals a Complex Inflammatory Environment Associated with Rupture
Intracranial aneurysm (IA) rupture leads to deadly subarachnoid hemorrhages. However, the mechanisms leading to rupture remain poorly understood. Altered gene expression within IA tissue is linked to the patho...
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Article
Endogenous animal models of intracranial aneurysm development: a review
The pathogenesis and natural history of intracranial aneurysm (IA) remains poorly understood. To this end, animal models with induced cerebral vessel lesions mimicking human aneurysms have provided the ability...
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Article
Open AccessCompliant vascular models 3D printed with the Stratasys J750: a direct characterization of model distensibility using intravascular ultrasound
The purpose of this study is to evaluate biomechanical accuracy of 3D printed anatomical vessels using a material jetting printer (J750, Stratasys, Rehovot, Israel) by measuring distensibility via intravascula...
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Article
Use of quantitative angiographic methods with a data-driven model to evaluate reperfusion status (mTICI) during thrombectomy
Intra-procedural assessment of reperfusion during mechanical thrombectomy (MT) for emergent large vessel occlusion (LVO) stroke is traditionally based on subjective evaluation of digital subtraction angiograph...
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Article
Open AccessIdentification of intima-to-media signals for flow-induced vascular remodeling using correlative gene expression analysis
Changes in blood flow can induce arterial remodeling. Intimal cells sense flow and send signals to the media to initiate remodeling. However, the nature of such intima-media signaling is not fully understood. ...
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Article
Open AccessEpigenetic landscapes of intracranial aneurysm risk haplotypes implicate enhancer function of endothelial cells and fibroblasts in dysregulated gene expression
Genome-wide association studies have identified many single nucleotide polymorphisms (SNPs) associated with increased risk for intracranial aneurysm (IA). However, how such variants affect gene expression with...
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Article
Semi-automated measurement of vascular tortuosity and its implications for mechanical thrombectomy performance
Few studies have examined the geometry of endovascular mechanical thrombectomy pathways. Here we examine the tortuosity and angulations of catheter pathways from the aortic arch to the termination of the inter...
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Challenges in Thrombectomy: Impossible Aortic Arches and Tortuous Vessels
The goal of endovascular treatment is to achieve rapid and safe revascularization of brain tissue at risk for irreversible ischemic injury. Aortic arch anomalies and tortuosity of the vasculature pose a challe...
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Article
Characterization of Long Non-coding RNA Signatures of Intracranial Aneurysm in Circulating Whole Blood
Long non-coding RNAs (lncRNAs) may serve as biomarkers for complex disease states, such as intracranial aneurysms. In this study, we investigated lncRNA expression differences in the whole blood of patients wi...
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Article
Open AccessClassification models using circulating neutrophil transcripts can detect unruptured intracranial aneurysm
Intracranial aneurysms (IAs) are dangerous because of their potential to rupture. We previously found significant RNA expression differences in circulating neutrophils between patients with and without unruptu...
