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  1. No Access

    Article

    Modulation of histamine release by rat peritoneal mast cells in a superfusion set-up

    A new method is presented for studying mediator release in isolated peritoneal cells of the rat. Using a superfusion technique, cells can be maintained in a continuously cleared medium. Cells were stimulated w...

    M. J. Post, C. Moekoet, J. Wemer, H. H. van Rooij, A. J. Porsius in Agents and Actions (1990)

  2. No Access

    Article

    Adenosine enhances antigen-induced bronchoconstriction and histamine release in rat isolated lungs

    The effects of adenosine and some of its analogues on bronchoconstriction and mediator release were studied in isolated lungs of actively sensitized rats. Adenosine (ADO) and its analogues R-phenyl-isopropyl-a...

    M. J. Post, J. D. te Biesebeek, J. Wemer, H. H. van Rooij… in Agents and Actions (1990)

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    Article

    In vivo anaphylaxis in the rat: Effects of phosphodiesterase inhibitors

    On the basis of their inhibitory capacities on the phosphodiesterase enzyme system, we studied the anti-anaphylactic effect of milrinone and sulmazole in comparison with theophylline. For this purpose anaphyla...

    M. J. Post, J. D. te Biesebeek, J. Wemer, H. H. van Rooij… in Agents and Actions (1989)

  4. No Access

    Article

    Pharmacokinetics of lisinopril in hypertensive patients with normal and impaired renal function

    The pharmacokinetics of lisinopril was studied after administration of single and multiple doses of 5 mg to hypertensive patients with normal and impaired renal function.

    B. A. M. van Schaik, G. G. Geyskes… in European Journal of Clinical Pharmacology (1988)

  5. No Access

    Article

    Central effects of paraoxon on haemodynamics in the cat

    Application of paraoxon into the left vertebral artery (8–80 μg) or both the left and right vertebral artery (4–8 μg) of the anaesthetized cat evoked dose-dependent depressor effects, whereas heart rate was no...

    J. H. de Neef, A. J. Porsius in Naunyn-Schmiedeberg's Archives of Pharmacology (1981)

  6. No Access

    Article

    The effects of desmethylimipramine on the pharmacological actions of alpha methyldopa in man

    The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volu...

    J. L. Reid, A. J. Porsius, C. Zamboulis… in European Journal of Clinical Pharmacology (1979)

  7. No Access

    Chapter

    The Central Effect of Physostigmine on Blood Pressure and Heart Rate; Possible Cholinerg Aspects of Blood Pressure Regulation

    In recent years it has been established that central adrenergic mechanisms are involved in the regulation of blood pressure. However, less information is available concerning the central effects of cholinergic...

    D. de Wildt, A. J. Porsius in Deutsche Pharmakologische Gesellschaft (1978)

  8. No Access

    Article

    Anaesthetic agents and glycolysis

    The influence of halothane, chloroform and propanidid on hexokinase, phosphoglucose-isomerase and phosphofructokinase was studied in vitro. None of the three anaesthetic agents significantly inhibited the activit...

    A. J. Porsius, P. A. van Zwieten in Naunyn-Schmiedeberg's Archives of Pharmacology (1974)