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    Article

    Comparison of nonlinear mixed-effect and non-parametric expectation maximisation modelling for Bayesian estimation of carboplatin clearance in children

    Objective: The pharmacodynamic–pharmacokinetic relationships for carboplatin involve the area under the curve of ultrafiltrable plasma concentrations versus time (AUC). The objective of the study was to compare ...

    A. Patoux, N. Bleyzac, A. Boddy, F. Doz… in European Journal of Clinical Pharmacology (2001)