1 Result(s)

Article

Nuclear thymidylate synthase expression, p53 expression and 5FU response in colorectal carcinoma

Thymidylate synthase (TS) is a key enzyme in DNA synthesis and is inhibited by metabolites of the chemotherapeutic agent 5-fluorouracil (5FU). Nuclear expression of TS in human tissue in vivo has not been char...

N A C S Wong, L Brett, M Stewart, A Leitch, D B Longley… in British Journal of Cancer (2001)