8 Result(s)
within
A. Jennifer Morton
Biomedicine
-
Article
Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington’s disease is not improved by treatment with hypoglycaemic agents
The R6/2 transgenic mouse model of Huntington’s disease (HD) develops a progressive neurological phenotype that involves severe motor and cognitive dysfunctions. Although not a cardinal sign, diabetes has been...
-
Article
Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington’s disease
The histological hallmark feature of Huntington’s disease (HD) and other polyglutamine repeat diseases is the presence of intracellular inclusions. Much work has been devoted to trying to determine the relatio...
-
Chapter
Synaptic Dysfunction in Huntington’s Disease
Huntington’s disease (HD) is a progressive, inherited, neurodegenerative disorder characterised by movement abnormalities, cognitive impairments and emotional disturbance (Bates et al. 2002). The genetic mutation...
-
Article
Choosing an animal model for the study of Huntington's disease
Animal models of Huntington's disease (HD), which have been established in species that range from worms, fruitflies, mice and rats to pigs, sheep and monkeys,...
-
Article
Erratum to: Chronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington’s Disease Mice
-
Article
Open AccessChronic Paroxetine Treatment Prevents the Emergence of Abnormal Electroencephalogram Oscillations in Huntington’s Disease Mice
Disturbance of rapid eye movement (REM) sleep appears early in both patients with Huntington’s disease (HD) and mouse models of HD. Selective serotonin reuptake inhibitors are widely prescribed for patients wi...
-
Article
Open AccessIndices of comparative cognition: assessing animal models of human brain function
Understanding the cognitive capacities of animals is important, because (a) several animal models of human neurodegenerative disease are considered poor representatives of the human equivalent and (b) cognitiv...
-
Article
Open AccessWake-Promoting and EEG Spectral Effects of Modafinil After Acute or Chronic Administration in the R6/2 Mouse Model of Huntington’s Disease
Huntington’s disease (HD) is characterised by progressive symptoms including cognitive deficits and sleep/wake disturbances reflected in an abnormal electroencephalography (EEG). Modafinil, a wake-promoting an...
