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Article
Differential morphology and composition of inclusions in the R6/2 mouse and PC12 cell models of Huntington’s disease
The histological hallmark feature of Huntington’s disease (HD) and other polyglutamine repeat diseases is the presence of intracellular inclusions. Much work has been devoted to trying to determine the relatio...
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Synaptic Dysfunction in Huntington’s Disease
Huntington’s disease (HD) is a progressive, inherited, neurodegenerative disorder characterised by movement abnormalities, cognitive impairments and emotional disturbance (Bates et al. 2002). The genetic mutation...