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Article
Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)
Weight loss is a milestone in the prevention of chronic diseases associated with high morbility and mortality in industrialized countries. Very-low calorie ketogenic diets (VLCKDs) are increasingly used in cli...
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Article
The effect of parathyroid hormone (1–84) treatment on serum bone morphogenetic protein 4 and vascular endothelial growth factor in postmenopausal women with established osteoporosis
To investigate the effect of 18 months’ parathyroid hormone 1–84 (PTH 1–84) treatment on serum levels of bone morphogenetic protein 4 (BMP4) and vascular endothelial growth factor (VEGF), in postmenopausal wom...
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Article
Are severe hypoglycemic episodes in diabetes correctly identified by administrative data? Evidence of underreporting from the HYPOTHESIS study
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Article
A novel combined glucocorticoid-mineralocorticoid receptor selective modulator markedly prevents weight gain and fat mass expansion in mice fed a high-fat diet
We have previously shown that antagonism of the mineralocorticoid receptor (MR) results in a potent antiadipogenic activity, in vitro and in vivo. Excessive glucocorticoid exposure is associated with obesity and ...
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Article
Characterization of endocrine features and genotype–phenotypes correlations in blepharophimosis–ptosis–epicanthus inversus syndrome type 1
Blepharophimosis syndrome (BPES) is an autosomal dominant genetic condition resulting from heterozygous mutations in the FOXL2 gene and clinically characterized by an eyelid malformation associated (type I) or no...
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Article
First-line chemotherapy with planned sequential administration of cisplatin/gemcitabine followed by docetaxel in elderly ‘unfrail’ patients with advanced non-small-cell lung cancer: a multicenter phase II study
The role of cisplatin in the first-line treatment for elderly advanced non-small-cell lung cancer is not completely defined. We previously reported in this subset of patients an interesting efficacy and tolera...
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Article
Acupuncture in clinical and experimental reproductive medicine: A review
Background: Acupuncture has been used as treatment for infertility for hundreds of years, and recently it has been studied in male and female infertility and in assisted reproductive tech...
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Article
Epidemiology; diagnosis, and treatment of male hypogonadotropic hypogonadism
Hypogonadotropic hypogonadism (HH), or secondary hypogonadism, is a clinical condition due to an impairment of the pituitary function, characterized by low testosterone plasma levels associated with normal or ...
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Article
Reply to ‘Rituximab activity in CD20-positive multiple myeloma’
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Article
Reply to Rituximab activity in CD20 positive multiple myeloma
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Article
Are subjects with erectile dysfunction aware of their condition? Results from a retrospective study based on an Italian free-call information service
The aim of the study was to analyse the socio-demographic and epidemiological characteristics of the Italian male population affected by sexual disturbances. Men complaining of erectile dysfunction (ED) who ca...
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Article
Erectile dysfunction: Expectations beyond phosphodiesterase Type 5 inhibition
In the last few years the pathophysiological mechanisms of erection have been partially clarified, and the molecular machinery of the cellular components of the corpus cavernosum (CC) has been widely investiga...
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Article
Thyroid volume in type 1 diabetes patients without overt thyroid disease
An association between insulin-dependent diabetes mellitus (type 1) and thyroid diseases has long been reported, but the morphological evaluation of the thyroid in type 1 diabetes patients without overt thyroi...
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Article
Immunohistochemical localization of growth hormone-releasing hormone in human gonads
Human gonads were examined for the presence of ir growth hormone-releasing-hormone. We demonstrated the presence of immu-nostainable cells both in ovarian and in testicular tissue using a non-crossreactive ant...
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Article
Immunoreactive beta-endorphin levels in cerebrospinal fluid of children with acute lymphoblastic leukemia: relationship with glucocorticoid therapy and neurological complications
Neurological disorders, such as seizures, are not infrequently associated with antileukemic therapy. It has been hypothesized that a disrupted peptidergic transmission between neurons could be the cellular bas...