22 Result(s)
within
A. Botturi
Neurology
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Article
A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma
Medulloblastomas and high-grade gliomas (HGG) are two distinct brain tumor, with different peculiarities in terms of age of onset, localizations and prognosis. The coexistence of the two neoplasms in the same ...
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Article
Safety and efficacy of primary central nervous system lymphoma treatment in elderly population
Elderly patients represent an important subgroup in primary central nervous system lymphoma (PCNSL) that accounts for approximately half the cases. Furthermore age represents one of the heaviest prognostic fac...
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Article
Update on treatment strategies for anaplastic glioma: a review of literature
Anaplastic gliomas (AG) include 6–10% of all newly diagnoses of primary brain tumors. They have an unfavourable prognosis and, to date, there is not an established treatment universally recognized. Four recent...
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Article
Safety of bevacizumab in patients with malignant gliomas: a systematic review
Angiogenesis has recently become a major target for the development of new antineoplastic drugs. The most serious adverse events linked to angiogenesis inhibitors are venous or arterial thromboembolism and hae...
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Article
Liposomal cytarabine in neoplastic meningitis from primary brain tumors: a single institutional experience
Neoplastic meningitis (NM) is diagnosed in 1–2 % of patients with primary brain tumors. Standard treatment of NM includes single-agent or combination chemotherapy, with compounds such as methotrexate, thiotepa...
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Article
RETRACTED ARTICLE: Headaches and brain tumors
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Article
Brain tuberculoma (Mycobacterium africanum): high index of suspicion helps in avoiding biopsy/surgery
Partial seizures can be due to a growing cerebral lesion, which may be tumoral or inflammatory/infectious in nature. The differential diagnosis is obviously important; increasing immigration to Europe from Afr...
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Article
Adult medulloblastoma: multiagent chemotherapy with cisplatinum and etoposide: a single institutional experience
In 1991, a prospective phase II trial was initiated to evaluate the efficacy of treatment for adults with medulloblastoma (MB). After surgery, patients were staged with a neuroradiologic examination of the bra...
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Article
Lecture: fotemustine in brain tumors
Fotemustine (FTMS) is a third-generation nitrosourea, in preclinical studies, FTMS compared favorably with carmustine (BCNU) and lomustine (CCNU) against several human tumor cell lines. In conventional schedul...
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Article
Infections in neuro-oncology
Infections represent a serious and frequent complication in neuro-oncology patients. Decreased immune defences, along with poor nutritional status are the main predisposition factors. The combined therapeutic ...
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Article
Neuro-oncological diagnosis in patients without histological confirmation
The impossibility to conduct a histological diagnosis could be due to different reasons: (1) patient’s refusal to undergo surgery/biopsy. (2) Technical difficulties: despite the advance in surgical procedures,...
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Article
Metabolic, electrolytes disorders and tromboembolic risk in malignant glioma patients
In malignant gliomas, the management of symptoms and minimization of side effects assume major importance. Corticosteroids provide transient relief from neurological symptoms. However, treatment with steroids ...
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Article
Consent and awareness: mental conditions at diagnosis
Informed consent is often talked about in an abstract manner, as if consent and information necessarily have to go together, and almost as if consent is “naturally” the quintessence of a good professional rela...
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Article
Malignant gliomas: early diagnosis and clinical aspects
Brain tumor symptoms vary greatly from person to person because of two factors: location and size of tumors. The size of a tumor, however, does not necessarily affect the severity of symptoms. Manifestations d...
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Article
Privacy–solidarity conflict: the communication with the support group
Actually guidelines require that patient must be informed about his condition so that he can choose the persons he wants to share these information with. Nonetheless, the caregiver usually gets an intermediary...
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Article
Rechallenge with temozolomide in recurrent glioma
Despite a confirmed survival benefit associated with adjuvant radio- and chemotherapy, the majority of patients with malignant glioma relapse after initial therapy. Recurrent malignant glioma treatment has not...
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Article
Methotrexate based chemotherapy and deferred radiotherapy for primary central nervous system lymphoma (PCNSL): single institution experience
In the following study, we present our experience in the treatment of PCNSL patients using a multi-step schedule combining chemotherapy and deferred radiotherapy. Patients were treated with two modified M-BACO...
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Article
Meningitis following relapsing painful ophthalmoplegia in aspergillus sphenoidal sinusitis: a case report
We report the case of a 58-year-old woman in whom relapsing painful ophthalmoplegia related to a mycetoma of the sphenoid sinus gave origin to meningitis with markedly depressed glucose levels in the cerebrosp...
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Article
Systemic Temozolomide Combined with Loco-regional Mitoxantrone in Treating Recurrent Glioblastoma
Twenty-two recurrent GBM patients were enrolled for second tumor debulking with local positioning of a Rickam reservoir, in order to locally deliver chemotherapy with the aim of controlling local tumor recurre...
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Article
Local drug delivery in recurrent malignant gliomas
In recurrent malignant gliomas, we scheduled a protocol by adding to systemic temozolomide a local treatment delivered through a reservoire positioned in the surgically created cavity, consisting of either mit...
