20 Result(s)
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Article
Botulinum toxin treatment in patients with focal dystonia and hemifacial spasm. A multicenter study of the Italian Movement Disorder Group
In six Centers belonging to the Italian Movement Disorder Study Group, the efficacy of botulinum toxin treatment was evaluated in an open collaborative study in 251 patients with focal dystonia and hemifacial ...
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Article
A multicenter Italian randomised study on early treatment of Parkinson disease: comparison of 1-dopa, 1-deprenyl and dopaminoagonists. Study design and short term results
On the long term Parkinson Disease (PD) treatment is often complicated by the occurrence of motor fluctuations. To find out whether early treatment of PD with levodopa, dopaminoagonists or 1-deprenyl is associ...
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Article
Botulinum A toxin injection in patients with blepharospasm, torticollis and hemifacial spasm
Botulinum A toxin was injected into the affected muscles in 20 patients with blepharospasm, 8 with torticollis and 12 with hemifacial spasm. In all cases blepharospasm and hemifacial spasm was abolished or mar...
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Chapter
Differential diagnosis of Parkinson’s disease
Diagnosis of idiopathic Parkinson’s disease (PD) is essentially clinical and is reached by exclusion. An akinetic rigid syndrome frequently means PD, although a number of other neurodegenerative diseases can s...
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Chapter and Conference Paper
Subcutaneous lisuride infusion in Parkinson’s disease: clinical results using different modes of administration
The continuous dopaminergic stimulation provided by infusion of dopamine agonist drugs, is a very effective strategy to control ON-OFF fluctuation in Parkinson’s disease. Lisuride is a potent dopamine agonist ...
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Article
Multicenter trial of L-Deprenylin Parkinson disease
A multicenter trial was conducted at 9 Neurology Departements to evaluate the action of L-Deprenyl, a specific monoamine oxidase-B inhibitor, combined with L-Dopa in the treatment of Parkinson disease. In all,...
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Chapter and Conference Paper
Relevance of Dopaminergic Agonists and Antagonists to Parkinsonian Tremor
Tremor is the most complex symptom of Parkinson’s disease, either for physiopathology or for neurochemistry. It seems to be the result of a derangement of cortical-subcortical loops which in Parkinson’s diseas...
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Article
Prolactin response as an index of dopaminergic receptor function in Parkinson's disease. Correlation with clinical findings and therapeutic response
Circadian rhythms of prolactin have been evaluated in thirteen untreated parkinsonian patients before and after 15 days of treatment with L-Dopa + carbidopa. The 24th secretory pattern was not significatively ...
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Article
Dopaminergic and non-dopaminergic neurons in substantia nigra: Differential response to bromocriptine
Bromocriptine reduces the spontaneous firing rate of neurons in the pars compacta of the substantia nigra but does not change the electrical activity of the neurons located in the pars reticulata. On the other...
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Chapter and Conference Paper
Diagnosis
The indications and contra-indications for operative intervention in intracerebral haematomas are, in general, dependent on their pathogenesis. For this reason, pre-operative investigations, particularly contr...
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Chapter and Conference Paper
Introductory Remarks
Within the sphere of cerebrovascular diseases, both in the anatomo-pathologic and in the Physiopathologic fields, different pathogenic interpretations have been advanced which have not always been capable of w...
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Chapter and Conference Paper
Platelet Aggregation in Cerebrovascular Patients
The role of platelet embolism in cerebral ischemic lesions has recently been evaluated (Ross Russel, 1968; McBrien et al., 1963). How the platelet embolism is formed has yet to be clarified: is it set off by f...
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Article
Myelotomography in the diagnosis of lumbo-sacral disc prolapse
Myelotomography is of considerable help in the preoperative diagnosis of lumbo-sacral intervertebral disc prolapses. Contrast views and new water-soluble media make the technique very useful.
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Article
On the relationship between l-DOPA therapy and CSF monoamine metabolites in parkinson's disease
HVA, the main dopamine catabolite, was shown to be decreased in CSF of parkinsonian patients. A significant relationship was also shown between clinical improvement and HVA concentration increase in CSF. It wa...
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Article
Treatment of Parkinson's disease with l-DOPA and an association l-DOPA plus a DOPA decarboxylase inhibitor
l-DOPA therapy of Parkinsonism by mouth, today universally accepted, may induce undesirable effects which can sometimes be of a certain severity.
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Chapter
Measurements of rCBF by Intravenous Injection of 133Xe. A Comparative Study with the Intra-Arterial Injection Method
Clearance methods with radioactive inert gases injected into the internal carotid artery can be simplified. Actually, these methods seem essentialy limited to studies of clinical physiology.
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Chapter
Cerebral Vasomotor Control and CSF pH in Metabolic and Respiratory Coma
Regional CBF was measured in the resting state and during vasomotor tests, along with CSF acid-base status, in 15 patients comatose due to diffuse brain lesions (Table 1). Fig. 1 illustrates 1 patient, showing...
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Chapter
Discrepancies Between Autoregulation and CO2 Reactivity of Cerebral Vessels
The problem of the “discrepancies” that we raised at the Bonn and Lund Symposia in 1968, can be expressed by saying that a rigorous separation between entirely “good” and “bad” vessels does not often hold in p...
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Article
The hydrogen method of measuring local blood flow in subcortical structures of the brain: Including a comparative study with the 14C antipyrine method
A method of measuring local cerebral blood flow, on the basis of inhalation of hydrogen gas and subsequent recording of local clearance curves of hydrogen by means of platinum electrodes, has been tested under...
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Chapter
Lack of Adaptation of CBF and CSF pH in Hypoxic Hypercapnia
Previously [1] we reported that during chronic normoxic respiratory acidosis, lasting 8-11 h, the CSF pH tends to return toward normal values despite the persistence of acidosis in the blood. At the same time the...
