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  1. No Access

    Article

    RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia

    Acute myeloid leukemia (AML) with the FLT3 internal tandem duplication (FLT3-ITD AML) accounts for 20–30% of AML cases. This subtype usually responds poorly to conventional therapies, and might become resistant t...

    M-A Hospital, A Jacquel, F Mazed, E Saland, C Larrue, J Mondesir, R Birsen… in Leukemia (2018)

  2. No Access

    Article

    Pim kinases phosphorylate Chk1 and regulate its functions in acute myeloid leukemia

    Phosphorylation by Akt on Ser 280 was reported to induce cytoplasmic retention and inactivation of CHK1 with consequent genetic instability in PTEN−/− cells. In acute myeloid leukemia cells carrying the FLT3-i...

    L L Yuan, A S Green, S Bertoli, F Grimal, V Mansat-De Mas, C Dozier… in Leukemia (2014)

  3. No Access

    Article

    The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

    The serine/threonine kinase mammalian target of rapamycin (mTOR) is crucial for cell growth and proliferation, and is constitutively activated in primary acute myeloid leukemia (AML) cells, therefore represent...

    L Willems, N Chapuis, A Puissant, T T Maciel, A S Green, N Jacque, C Vignon… in Leukemia (2012)

  4. No Access

    Article

    Perspectives on inhibiting mTOR as a future treatment strategy for hematological malignancies

    Mammalian target of rapamycin (mTOR) is a protein kinase implicated in the regulation of various cellular processes, including those required for tumor development, such as the initiation of mRNA translation, ...

    N Chapuis, J Tamburini, A S Green, L Willems, V Bardet, S Park, C Lacombe… in Leukemia (2010)