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Article
Glutathione-s-transferase pi expression in leukaemia: a comparative analysis with mdr-1 data
Drug resistance in haemopoietic cells may be partly related to the expression of the glutathione-s-transferase (GST) pi and mdr-1 genes. We have used RNA slot blotting techniques to investigate the expression ...
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Article
Ferritin-bearing T-lymphocytes and serum ferritin in patients with breast cancer
Flow cytometric studies of T-lymphocytes in breast cancer patients show that the number of cells bearing ferritin on their surface is significantly greater than normal. The number of ferritin-bearing T-cells d...
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Article
Human preleukaemia: do we have a model?
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Article
Anaemia in patients with myelomatosis
Twenty-four untreated patients with myelomatosis were studied in order to characterize their anaemia, using standard haematological and ferrokinetic techniques, together with measurements of circulating erythr...
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Article
Erythropoiesis and iron metabolism in Hodgkin's disease
Recently developed techniques for the investigation of iron kinetics were used to study the disturbance of iron metabolism in 19 untreated patients with Hodgkin's diseases (HD). The erythroid abnormality in ne...
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Article
Isoferritins in acute leukaemia
Leucocytes containing a high proportion of blast cells were obtained from 11 patients with acute myeloid leukaemia, and leucocytes were also obtained from 2 normal subjects. Ferritin was partially purified fro...
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Article
Serum ferritin concentration in early breast cancer
The concentration of circulating ferritin was measured in 250 normal adult women and 229 women presenting with early breast cancer. Ferritin concentrations are higher in cancer patients than in normal women. P...
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Article
Serum ferritin concentration in untreated Hodgkin's disease
Serum ferritin has been estimated in 125 untreated patients with Hodgkin's disease. Increasing concentrations are found at each advancing stage of the disease and high concentrations are found in patients with...
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Article
Letter: Serum ferritin, alpha2 H globulin and malignant disease
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Article
Ferritinaemia in Leukaemia and Hodgkin's Disease
The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease. In acute leukaemia the mean concentration is about ten times the normal level and is associated with a ...
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Article
Iron Metabolism in Hodgkin's Disease
An evaluation of iron metabolism has been carried out in 23 untreated patients with Hodgkin's disease and 6 patients with other lymphomata. The reduction in red cell life span is related to the stage of the di...
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Article
Anaemia and Post-Cricoid Carcinoma