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A J Eustace
Drug Resistance
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Article
Open AccessMembrane transport proteins in human melanoma: associations with tumour aggressiveness and metastasis
Malignant melanoma, generally described as incurable, is notoriously refractory to chemotherapy. The mechanisms contributing to this have not yet been defined and the contributions of drug efflux pumps, implic...
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Article
Open AccessContribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells
Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although the mechanistic basis is unclear. This study sought to investig...
