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  1. No Access

    Article

    Transformation suppressor activity of C3G is independent of its CDC25-homology domain

    The guanine nucleotide releasing protein C3G was initially identified as a Crk SH3-binding protein and recently shown to exhibit exchange activity on Rap1 proteins. Overexpression in NIH3T3 cells of a full-len...

    C Guerrero, A Fernandez-Medarde, JM Rojas, J Font de Mora, LM Esteban, E Santos in Oncogene (1998)

  2. Article

    p73 cooperates with Ras in the activation of MAP kinase signaling cascade

    The p73 gene is capable of inducing cell cycle arrest, apoptosis, senescence, differentiation and to cooperate with oncogenic Ras in cellular transformation. Ras can be considered as a branch point in signal tran...

    B Fernandez-Garcia, J P Vaqué, M Herreros-Villanueva… in Cell Death & Differentiation (2007)

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    Article

    Sos1 disruption impairs cellular proliferation and viability through an increase in mitochondrial oxidative stress in primary MEFs

    Using a 4-hydroxytamoxifen (4OHT)-inducible, conditional Sos1-null mutation, we analyzed wild-type (WT), single Sos1-KO, Sos2-KO and double Sos1/2 KO primary mouse embryonic fibroblasts (MEF) with an aim at ev...

    P Liceras-Boillos, R García-Navas, A Ginel-Picardo, B Anta, M Pérez-Andrés… in Oncogene (2016)