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3 Result(s)

within A Bonehill Remove this filter Human Genetics Remove this filter

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  1. No Access

    Article

    Induction of antigen-specific CD8+ cytotoxic T cells by dendritic cells co-electroporated with a dsRNA analogue and tumor antigen mRNA

    The maturation state of dendritic cells (DCs) is an important determinant for the initiation and regulation of adaptive immune responses. In this study, we wanted to assess whether functional activation of hum...

    A Michiels, K Breckpot, J Corthals, S Tuyaerts, A Bonehill, C Heirman… in Gene Therapy (2006)

  2. No Access

    Article

    Induction of effective therapeutic antitumor immunity by direct in vivo administration of lentiviral vectors

    Ex vivo lentivirally transduced dendritic cells (DC) have been described to induce CD8+ and CD4+ T-cell responses against various tumor-associated antigens (TAAs) in vitro and in vivo. We report here that direct ...

    M Dullaers, S Van Meirvenne, C Heirman, L Straetman, A Bonehill, J L Aerts… in Gene Therapy (2006)

  3. No Access

    Article

    Electroporation of immature and mature dendritic cells: implications for dendritic cell-based vaccines

    Until now, studies utilizing mRNA electroporation as a tool for the delivery of tumor antigens to human monocyte-derived dendritic cells (DC) have focused on DC electroporated in an immature state. Immature DC...

    A Michiels, S Tuyaerts, A Bonehill, J Corthals, K Breckpot, C Heirman… in Gene Therapy (2005)