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  1. No Access

    Article

    Nomogram to predict radicular grooves in maxillary lateral incisors in preoperative orthodontic population

    This study aimed to develop and validate a predictive nomogram for diagnosing radicular grooves (RG) in maxillary lateral incisors (MLIs), integrating demographic information, anatomical measurements, and Cone...

    **uneng Zhou, Jie Deng, Nianke Liu, Chunhui Yang, Shiyu Li in Clinical Oral Investigations (2024)

  2. Article

    Open Access

    Nociceptive adenosine A2A receptor on trigeminal nerves orchestrates CGRP release to regulate the progression of oral squamous cell carcinoma

    Oral squamous cell carcinoma (OSCC) associated pain commonly predicts adverse events among patients. This clinical feature indicates the engagement of nociceptors on sensory neurons during the development of m...

    Lanxin Jiang, Ying Zhou, Shijie Tang, Dan Yang in International Journal of Oral Science (2024)

  3. Article

    Open Access

    Expert consensus on endodontic therapy for patients with systemic conditions

    The overall health condition of patients significantly affects the diagnosis, treatment, and prognosis of endodontic diseases. A systemic consideration of the patient’s overall health along with oral condition...

    **n Xu, **n Zheng, Fei Lin, Qing Yu, Benxiang Hou in International Journal of Oral Science (2024)

  4. Article

    Open Access

    Integrative single-cell and bulk transcriptomes analyses reveals heterogeneity of serine-glycine-one-carbon metabolism with distinct prognoses and therapeutic vulnerabilities in HNSCC

    Metabolic heterogeneity plays a central role in sustaining uncontrolled cancer cell proliferation and sha** the tumor microenvironment (TME), which significantly compromises the clinical outcomes and respons...

    Lixuan Wang, Rongchun Yang, Yue Kong, **g Zhou in International Journal of Oral Science (2024)

  5. Article

    Open Access

    A comparative study of microbial changes in dental plaque before and after single- and multiappointment treatments in patients with severe early childhood caries

    The status of dental caries is closely related to changes in the oral microbiome. In this study, we compared the diversity and structure of the dental plaque microbiome in children with severe early childhood ...

    Shi Ying Ma, Qing Nan Zhou, Shuang Cai, Yan Zhou, **ao Yu Zhang in BMC Oral Health (2024)

  6. Article

    Open Access

    Cone-wedge anchored surgical templates for stackable metal guide: a novel technique

    To address the instability in implant surgical guides, this technique proposes an alternative anchoring mechanism in the stackable metal surgical guides utilizing cone-wedge anchors for improved stability.

    Xueying Bai, Tao Wu, Yuxi Zhu, Chengyu Yang in International Journal of Implant Dentistry (2024)

  7. Article

    Open Access

    Efficacy of Danzhixiaoyao tablets combined with methylcobalamin tablets in the treatment of burning mouth syndrome: an open-label, randomized controlled trial

    This randomized controlled trial compared the efficacy and tolerability of danzhixiaoyao pills in the accurate treatment of patients with burning mouth syndrome (BMS).

    Ya Gao, **gwen Yang, Huimin Sun, Haiwen Zhou in BMC Oral Health (2024)

  8. Article

    Open Access

    Oral frailty: a concept analysis

    Oral frailty has become a worldwide problem among older adults. Although researchers have conducted various studies on oral frailty, its definition remains controversial.

    Huimin Zhao, Bei Wu, Yuqiu Zhou, Zhilan Yang, Hua Zhao, Ziwei Tian in BMC Oral Health (2024)

  9. Article

    Open Access

    Malignant transformation of white sponge nevus: a case report of a novel keratin 4 mutation

    White Sponge Nevus (WSN) is traditionally considered a benign genetic disorder affecting the oral mucosa, primarily caused by pathogenic mutations in keratin 4 (KRT4) or keratin 13 (KRT13). Despite its benign nat...

    Dan Liu, Tianyu Zhang, Hangfan Zhou, Chuanji Wu, Taiwen Li, Lu Jiang in BMC Oral Health (2024)

  10. No Access

    Article

    Feasibility study of a novel digital template-guided flapless extraction for maxillary palatal impacted teeth

    With the increasing maturity of 3D printing technology, the application of digital guide template in the extraction of impacted teeth has become more sophisticated. However, for maxillary palatal deeply impact...

    Qi Xu, ****g Bai, **an Zhou, Mengdie Chen, Yue Li in Clinical Oral Investigations (2024)

  11. Article

    Open Access

    Human dental pulp stem cells mitigate the neuropathology and cognitive decline via AKT-GSK3β-Nrf2 pathways in Alzheimer’s disease

    Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer’s disease (AD), particularly in the early stages of the disease. The multiplicity advantages of stem cell ...

    Wei **ong, Ye Liu, Heng Zhou, Junyi Li in International Journal of Oral Science (2024)

  12. Article

    Open Access

    Simultaneous detection of dental caries and fissure sealant in intraoral photos by deep learning: a pilot study

    Deep learning, as an artificial intelligence method has been proved to be powerful in analyzing images. The purpose of this study is to construct a deep learning-based model (ToothNet) for the simultaneous det...

    Yanshan **ong, Hongyuan Zhang, Shiyong Zhou, Minhua Lu, Jiahui Huang in BMC Oral Health (2024)

  13. Article

    Open Access

    Correction to: Computational fluid dynamics investigation on the irrigation of a real root canal with a side-vented needle

    Mingzhou Yu, Yi Li, Mengdie Zhao, Zhengqiu Huang, Na Zhou, Hanhui ** in BMC Oral Health (2024)

  14. Article

    Open Access

    Full life cycle changes of low impacted mandibular third molar associated cystic lesions and adjacent tooth root resorption: a retrospective study

    Low impacted third molars are usually asymptomatic and are often found by X-ray examination. The removal of asymptomatic low impacted third molars is one of the most controversial clinical issues in oral and m...

    Jiankang Zhang, Kun Zhang, Xueer Zhou, Li Ye, Yuanyuan Liu, Yiran Peng in BMC Oral Health (2024)

  15. No Access

    Article

    Identification of a novel de novo mutation in SOX4 for syndromic tooth agenesis

    Coffin-Siris Syndrome (CSS) is a congenital disorder characterized by delayed growth, dysmorphic facial features, hypoplastic nails and phalanges of the fifth digit, and dental abnormalities. Tooth agenesis ha...

    Mengqi Zhou, Feng Wang, Qinggang Dai, Jiaqi Dou, Yiqun Wu in Clinical Oral Investigations (2024)

  16. Article

    Open Access

    Multi-omics analysis of immune-related microbiome and prognostic model in head and neck squamous cell carcinoma

    The aim of our study is to explore the transcriptional and microbial characteristics of head and neck cancer’s immune phenotypes using a multi-omics approach.

    Yingqiao Liu, Haitao Lin, Weijun Zhong, Yudi Zeng in Clinical Oral Investigations (2024)

  17. Article

    Open Access

    Comparison of temporomandibular joints in relation to ages and vertical facial types in skeletal class II female patients: a multiple-cross-sectional study

    The temporomandibular joint (TMJ) is closely related to the dynamic balance and stability of mandibular function and orthodontic treatment. Skeletal class II female patients are thought to be at high risk for ...

    **g Zhou, Huifang Yang, Qing Li, Weiran Li, Yi Liu in BMC Oral Health (2024)

  18. Article

    Open Access

    Expert consensus on pediatric orthodontic therapies of malocclusions in children

    Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts the dental-maxillofacial functions, facial esthetics, and long-term development of ~260 m...

    Chenchen Zhou, Peipei Duan, Hong He, **lin Song in International Journal of Oral Science (2024)

  19. Article

    Open Access

    Single cell analysis unveils B cell-dominated immune subtypes in HNSCC for enhanced prognostic and therapeutic stratification

    Head and neck squamous cell carcinoma (HNSCC) is characterized by high recurrence or distant metastases rate and the prognosis is challenging. There is mounting evidence that tumor-infiltrating B cells (TIL-Bs...

    Kang Li, Caihua Zhang, Ruoxing Zhou in International Journal of Oral Science (2024)

  20. Article

    Open Access

    Mean platelet volume is associated with periodontitis: a cross-sectional study

    It is uncertain if mean platelet volume and periodontitis are related. The objective of this study was to examine the association between levels of mean platelet volume and moderate/severe periodontitis in adu...

    Chenying Zhou, Ye Liu, **g**g Bai, Yi Luo, Jukun Song, ** Feng in BMC Oral Health (2024)

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