-
Article
A New Characterization of \(L^2\) -Domains of Holomorphy with Null Thin Complements via \(L^2\) -Optimal Conditions
In this paper, we show that the \(L^2\) L 2 ...
-
Article
Open AccessDevelo** an optimal stratification model for colorectal cancer screening and reducing racial disparities in multi-center population-based studies
Early detection of colorectal neoplasms can reduce the colorectal cancer (CRC) burden by timely intervention for high-risk individuals. However, effective risk prediction models are lacking for personalized CR...
-
Article
Open AccessGenome-wide enhancer RNA profiling adds molecular links between genetic variation and human cancers
Dysregulation of enhancer transcription occurs in multiple cancers. Enhancer RNAs (eRNAs) are transcribed products from enhancers that play critical roles in transcriptional control. Characterizing the genetic...
-
Article
Variational quantum algorithms: fundamental concepts, applications and challenges
Quantum computing is a new discipline combining quantum mechanics and computer science, which is expected to solve technical problems that are difficult for classical computers to solve efficiently. At present...
-
Article
Tungsten chalcogenides as anodes for potassium-ion batteries
Potassium-ion batteries (PIBs) by virtue of their strong cost competitiveness and similar electrochemical properties to lithium-ion batteries have been deemed to be a promising electrochemical energy storage t...
-
Article
Open AccessHousehold air pollution and urinary incontinence symptoms among older adults in LASI: a large-scale population-based study
The effects of household air pollution on urinary incontinence (UI) symptoms and stress urinary incontinence (SUI) symptoms have not been studied. This study seeks to investigate the correlation between househ...
-
Article
Open AccessGalectin-receptor interaction: a key player in liver fibrosis induced by Schistosoma japonicum infection
Schistosoma japonicum eggs lodge in the liver and induce a fibrotic granulomatous immune response in the liver of host. Galectin 3 (Gal-3) is a protein implicated in fibrosis in multiple organs. However, the path...
-
Article
Open AccessAlleviation of migraine related pain and anxiety by inhibiting calcium-stimulating AC1-dependent CGRP in the insula of adult rats
Recent animal and clinical findings consistently highlight the critical role of calcitonin gene-related peptide (CGRP) in chronic migraine (CM) and related emotional responses. CGRP antibodies and receptor ant...
-
Article
Open AccessCurrent advances and future trends of hormesis in disease
Hormesis, an adaptive response, occurs when exposure to low doses of a stressor potentially induces a stimulatory effect, while higher doses may inhibit it. This phenomenon is widely observed across various or...
-
Article
Judgmentally adjusted Q-values based on Q-ensemble for offline reinforcement learning
Recent advancements in offline reinforcement learning (offline RL) have leveraged the Q-ensemble approach to derive optimal policies from static datasets collected in the past. By increasing the batch size, a ...
-
Article
Hollow versatile Ag@Pt alloy nanoparticles with nanozyme activity for detection and photothermal sterilization of Helicobacter pylori
In view of a large number of people infected with Helicobacter pylori (H. pylori) with great harm followed, there is an urgent need to develop a non-invasive, easy-to-operate, and rapid detection method, and to i...
-
Article
Investigation of thermal desorption characteristics and pilot-scale study of polycyclic aromatic hydrocarbons (PAHs)-contaminated soil during cement manufacturing
This study encompassed lab-scale thermal desorption experiments and pilot-scale demonstration of soil contaminated with polycyclic aromatic hydrocarbons (PAHs) during cement manufacturing. The lab-scale experi...
-
Article
A segmentation method based on boundary fracture correction for froth scale measurement
During the mineral flotation process, the size characteristics of the surface froth significantly influence the production indicators of the flotation process. However, the information within froth images is i...
-
Article
Plastic film mulch use efficiency in agricultural production: a regional analysis in China
While the use of mulch film in agricultural production has contributed to higher yields and improved crop quality in the short term, the long-term accumulation of residual plastic in farmland soils has led to ...
-
Article
Open AccessCharacteristics, predictors and outcomes of new-onset QT prolongation in sepsis: a multicenter retrospective study
Sepsis-induced myocardial injury is a serious complication of sepsis. QT prolongation is a proarrhythmic state which reflects myocardial injury in a group of heterogeneous disorders. However, the study on the ...
-
Article
Open AccessLarge-scale analysis of the ARF and Aux/IAA gene families in 406 horticultural and other plants
The auxin response factor (ARF) and auxin/indole-3-acetic acid (Aux/IAA) family of genes are central components of the auxin signaling pathway and play essential roles in plant growth and development. Their la...
-
Article
Myelomonocytic and monocytic acute myeloid leukemia demonstrate comparable poor outcomes with venetoclax-based treatment: a monocentric real-world study
Venetoclax (VEN), a BCL-2 inhibitor, has transformed treatment strategies for elderly and unfit acute myeloid leukemia (AML) patients by significantly improving response rates and survival. However, the predic...
-
Article
Uncovering the Cellular Microenvironment in Chronic Rhinosinusitis via Single-Cell RNA Sequencing: Application and Future Directions
Chronic rhinosinusitis (CRS) is a heterogenic disease characterized by persistent mucosal inflammation of the upper airway. Researches of CRS have progressed from phenotype-based to endotype-based, looking mor...
-
Article
Open AccessInsomnia and anxiety among COVID-19 patients in China: the chain mediating effect of psychological capital and self-esteem
The outbreak of Corona Virus Disease (COVID-19) in 2019 has continued until now, posing a huge threat to the public’s physical and mental health, resulting in different degrees of mental health problems. As a ...
-
Article
Open AccessNomogram predicting the efficacy of transurethral surgery in benign prostatic hyperplasia patients
This study aimed to develop and validate a nomogram for predicting the efficacy of transurethral surgery in benign prostatic hyperplasia (BPH) patients.
