2,466 Result(s)
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**zhong Zhang
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Article
Open AccesslncRNA FLJ20021 regulates CDK1-mediated PANoptosis in a ZBP1-dependent manner to increase the sensitivity of laryngeal cancer-resistant cells to cisplatin
In this study, we investigated the role of the newly discovered lncRNA FLJ20021 in laryngeal cancer (LC) and its resistance to cisplatin treatment. We initially observed elevated lncRNA FLJ20021 levels in cisp...
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Acquired immune thrombotic thrombocytopenic purpura (TTP) associated with inactivated COVID-19 vaccine CoronaVac
Corona virus disease 2019 (COVID-19) due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has affected the whole world. Acquired thrombotic thrombocytopenic purpura (TTP) has been repo...
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Fabricating bio-inspired high impact resistance carbon nanotube network films for multi-protection under an extreme environment
The fabrication of light-weight, highly impact-resistant, and energy-absorbent materials is urgently demanded in many facets of the society from body armor to aerospace engineering, especially under an extreme...
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Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of Stapokibart in Healthy Volunteers and Adult Subjects with Atopic Dermatitis
Stapokibart, a novel humanized anti-interleukin (IL)-4 receptor alpha monoclonal antibody, inhibits the signaling of IL-4 and IL-13, which are key drivers of type 2 inflammation in atopic dermatitis (AD). This...
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AI-based MOA fault diagnosis mechanism in wireless networks
Metal oxide arrester (MOA) is an electric power equipment used to limit overvoltage and cooperate insulation between generator substation and direct current converter station. In the actual operation of MOA, d...
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Homodimeric peptide radiotracer [68Ga]Ga-NOTA-(TMVP1)2 for VEGFR-3 imaging of cervical cancer patients
Vascular endothelial growth factor receptor 3 (VEGFR-3) plays a critical role in tumor lymphangiogenesis and metastasis, holding promise as a promising therapeutic target for solid tumors. TMVP1 (LARGR) is a 5...
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Freezing strain characteristics and mechanisms of unsaturated frozen soil: analysis of matric suction and water–ice phase change
The freezing strain characteristics of unsaturated soil are quite different from those of saturated soil. Besides the commonly observed frost heave, unsaturated soil may also experience frost shrinkage, causin...
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Open AccessTranscriptome profiling of fast/glycolytic and slow/oxidative muscle fibers in aging and obesity
Aging and obesity pose significant threats to public health and are major contributors to muscle atrophy. The trends in muscle fiber types under these conditions and the transcriptional differences between dif...
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A ratiometric fluorescence and colorimetry dual-signal sensing strategy based on o-phenylenediamine and AuNCs for determination of Cu2+ and glyphosate
A ratiometric fluorescence sensing strategy has been developed for the determination of Cu2+ and glyphosate with high sensitivity and specificity based on OPD (o-phenylenediamine) and glutathione-stabilized gold ...
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Robot-assisted system for non-invasive wide-range flexible eye positioning and tracking in particle radiotherapy
Particle (proton, carbon ion, or others) radiotherapy for ocular tumors is highly dependent on precise dose distribution, and any misalignment can result in severe complications. The proposed eye positioning a...
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Open AccessMulti-UAV pursuit-evasion gaming based on PSO-M3DDPG schemes
The sample data for reinforcement learning algorithms often exhibit sparsity and instability, making the training results susceptible to falling into local optima. Mini-Max-Multi-agent Deep Deterministic Polic...
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Involvement of CgHSFB1 in the regulation of self-incompatibility in ‘Shatian’ pummelo
As self-incompatibility is a major issue in pummelo breeding and production, its mechanism in citrus was analyzed to improve breeding efficiency and reduce production costs. Rutaceae belongs to S-RNase type of ga...
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Open AccessATP biosensor reveals microbial energetic dynamics and facilitates bioproduction
Adenosine-5’-triphosphate (ATP), the primary energy currency in cellular processes, drives metabolic activities and biosynthesis. Despite its importance, understanding intracellular ATP dynamics’ impact on bio...
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Open AccessIncreased triacylglycerol production in Rhodococcus opacus by overexpressing transcriptional regulators
Lignocellulosic biomass is currently underutilized, but it offers promise as a resource for the generation of commercial end-products, such as biofuels, detergents, and other oleochemicals. Rhodococcus opacus PD6...
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Open AccessThe impact of telecom industry employees’ stress perception on job burnout: moderated mediation model
The rapid development of the telecommunications industry in the post-COVID-19 era has brought tremendous pressure to employees making them a high-risk group for job burnout. However, prior research paid less a...
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Open AccessMulti role ChatGPT framework for transforming medical data analysis
The application of ChatGPTin the medical field has sparked debate regarding its accuracy. To address this issue, we present a Multi-Role ChatGPT Framework (MRCF), designed to improve ChatGPT's performance in m...
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Predicting the potential deterioration of Barrett’s esophagus based on gut microbiota: a Mendelian randomization analysis
Esophageal adenocarcinoma (EAC) is one of the most malignant tumors in the digestive system. To make thing worse, the scarcity of treatment options is disheartening. However, if detected early, there is a poss...
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Open AccessAn ultra-short-acting benzodiazepine in thalamic nucleus reuniens undermines fear extinction via intermediation of hippocamposeptal circuits
Benzodiazepines, commonly used for anxiolytics, hinder conditioned fear extinction, and the underlying circuit mechanisms are unclear. Utilizing remimazolam, an ultra-short-acting benzodiazepine, here we revea...
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Open AccessRisk of internal fixation treatment in intertrochanteric fracture based on different lateral femoral wall thickness: finite element analysis
The thickness of the lateral femoral wall, which is an important indicator for evaluating the stability and integrity of intertrochanteric fractures, has been widely studied in recent years. However, as a typi...
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Open AccessStructure of cryptophyte photosystem II–light-harvesting antennae supercomplex
Cryptophytes are ancestral photosynthetic organisms evolved from red algae through secondary endosymbiosis. They have developed alloxanthin-chlorophyll a/c2-binding proteins (ACPs) as light-harvesting complexes (...
