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Article
A Nonparametric Model Checking Test for Functional Linear Composite Quantile Regression Models
This paper is focused on the goodness-of-fit test of the functional linear composite quantile regression model. A nonparametric test is proposed by using the orthogonality of the residual and its conditional e...
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Article
Molecular dynamics study on nanogrinding behavior of lamellar heterostructure gallium nitride
Lamellar heterostructures containing gallium nitride (GaN) have excellent photoelectric properties and also play an important role in lighting, the quantum field, and other fields. Exploring the nanoscale proc...
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Article
Open AccessUltra-wide band gap and wave attenuation mechanism of a novel star-shaped chiral metamaterial
A novel hollow star-shaped chiral metamaterial (SCM) is proposed by incorporating chiral structural properties into the standard hollow star-shaped metamaterial, exhibiting a wide band gap over 1 500 Hz. To br...
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Article
In vivo AAV–SB-CRISPR screens of tumor-infiltrating primary NK cells identify genetic checkpoints of CAR-NK therapy
Natural killer (NK) cells have clinical potential against cancer; however, multiple limitations hinder the success of NK cell therapy. Here, we performed unbiased functional map** of tumor-infiltrating NK (T...
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Article
Open AccessCharacterization and Genome Analysis of the Delftia lacustris Strain LzhVag01 Isolated from Vaginal Discharge
Delftia has been separated from freshwater, sludge, and soil and has emerged as a novel opportunistic pathogen in the female vagina. However, the genomic characteristics, pathogenicity, and biotechnological prope...
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Article
Open AccessCognitive function of children with biliary atresia after primary living donor liver transplantation
The survival rate of children with biliary atresia (BA) after liver transplantation (LT) is significantly improved, and their quality of life has attracted much attention.This study aimed to investigate the co...
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Article
Configuring Factors Influencing Science Teachers’ Intention to Use Virtual Experiments in China: An fsQCA-Based Study
The multiple benefits of virtual experiments applied to science education depend heavily on science teachers’ intentions to use them. The inducing mechanism is a process that combines different conditions of m...
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Article
Mechanical Behavior Based on Aggregates Microstructure of Ultra-high Performance Concrete
We developed ultra-high performance concrete (UHPC) incorporating mullite sand and brown corundum sand (BCS), and the quartz sand UHPC was utilized to prepare for comparison. The properties of compressive stre...
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Article
Open AccessBio-distribution and toxicity potential of human umbilical cord mesenchymal stem cells in cynomolgus monkeys
Mesenchymal stem cells (MSCs) have demonstrated promising advantages in the therapies of many diseases, while its multi-directional differentiation potential and immunotoxicity are the major concerns hindered ...
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Article
Simultaneous Search and Tracking of Non-cooperative Mobile Targets Using Multiple UAVs in Uneven Environments
This paper considers the simultaneous search and tracking problem of non-cooperative moving objects in unknown environments for unmanned aerial vehicle (UAV) swarms. The inherent ambiguities in target characte...
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Article
Open AccessMethodology and real-world applications of dynamic uncertain causality graph for clinical diagnosis with explainability and invariance
AI-aided clinical diagnosis is desired in medical care. Existing deep learning models lack explainability and mainly focus on image analysis. The recently developed Dynamic Uncertain Causality Graph (DUCG) app...
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Article
Open AccessA DNA demethylase reduces seed size by decreasing the DNA methylation of AT-rich transposable elements in soybean
Understanding how to increase soybean yield is crucial for global food security. The genetic and epigenetic factors influencing seed size, a major crop yield determinant, are not fully understood. We explore t...
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Article
Open AccessAutonomous navigation and collision prediction of port channel based on computer vision and lidar
This study aims to enhance the safety and efficiency of port navigation by reducing ship collision accidents, minimizing environmental risks, and optimizing waterways to increase port throughput. Initially, a ...
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Article
Anti-freezing Dough for Renewable and Reconfigurable Flexible Strain Sensors
With the rapid development of the Internet of Things technology, flexible strain sensors that facilitate bidirectional communication between humans and machines will play an important role. On the one hand, fl...
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Article
Rank-based instrumental variable estimation for semiparametric varying coefficient spatial autoregressive models
In this paper, it is aim to propose an instrumental variable rank estimation method for varying coefficient spatial autoregressive models. The newly proposed method provides a highly efficient and robust alter...
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Article
Open AccessAdvancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy
Meningeal lymphatic vessels (mLVs) play a pivotal role in regulating metabolic waste from cerebrospinal fluid (CSF). However, the current limitations in field of view and resolution of existing imaging techniq...
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Article
Discovery of a novel SHP2 allosteric inhibitor using virtual screening, FMO calculation, and molecular dynamic simulation
SHP2 is a non-receptor protein tyrosine phosphatase to remove tyrosine phosphorylation. Functionally, SHP2 is an essential bridge to connect numerous oncogenic cell-signaling cascades including RAS-ERK, PI3K-A...
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Article
Open AccessProgression from ductal carcinoma in situ to invasive breast cancer: molecular features and clinical significance
Ductal carcinoma in situ (DCIS) represents pre-invasive breast carcinoma. In untreated cases, 25–60% DCIS progress to invasive ductal carcinoma (IDC). The challenge lies in distinguishing between non-progressi...
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Article
Open AccessAmyloid β oligomer induces cerebral vasculopathy via pericyte-mediated endothelial dysfunction
Although abnormal accumulation of amyloid beta (Aβ) protein is thought to be the main cause of Alzheimer’s disease (AD), emerging evidence suggests a pivotal vascular contribution to AD. Aberrant amyloid β ind...
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Article
Open AccessIdentification and validation of RNA-binding protein SLC3A2 regulates melanocyte ferroptosis in vitiligo by integrated analysis of single-cell and bulk RNA-sequencing
The pathogenesis of vitiligo remains unclear. The genes encoding vitiligo-related RNA-binding proteins (RBPs) and their underlying pathogenic mechanism have not been determined.
