60 Result(s)
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Open AccessAI models predicting breast cancer distant metastasis using LightGBM with clinical blood markers and ultrasound maximum diameter
Breast cancer metastasis significantly impacts women's health globally. This study aimed to construct predictive models using clinical blood markers and ultrasound data to predict distant metastasis in breast ...
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Open AccessTrends in maternal and child health in China and its urban and rural areas from 1991 to 2020: a joinpoint regression model
The long-term trends in maternal and child health (MCH) in China and the national-level factors that may be associated with these changes have been poorly explored. This study aimed to assess trends in MCH ind...
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Author Correction: High-speed and large-scale intrinsically stretchable integrated circuits
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Open AccessCatalytic polymer self-cleavage for CO2 generation before combustion empowers materials with fire safety
Polymeric materials, rich in carbon, hydrogen, and oxygen elements, present substantial fire hazards to both human life and property due to their intrinsic flammability. Overcoming this challenge in the absenc...
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Open AccessReciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer
Squamous cell carcinomas (SCCs) are common and aggressive malignancies. Immune check point blockade (ICB) therapy using PD-1/PD-L1 antibodies has been approved in several types of advanced SCCs. However, low r...
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Open AccessPrediction model and assessment of malnutrition in patients with stable chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) combined with malnutrition results in decreased exercise capacity and a worse quality of life. We aimed to develop an observational case–control study to explore th...
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High-speed and large-scale intrinsically stretchable integrated circuits
Intrinsically stretchable electronics with skin-like mechanical properties have been identified as a promising platform for emerging applications ranging from continuous physiological monitoring to real-time a...
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Open AccessShape-changing electrode array for minimally invasive large-scale intracranial brain activity map**
Large-scale brain activity map** is important for understanding the neural basis of behaviour. Electrocorticograms (ECoGs) have high spatiotemporal resolution, bandwidth, and signal quality. However, the inv...
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Open AccessMetal-support interaction boosts the stability of Ni-based electrocatalysts for alkaline hydrogen oxidation
Ni-based hydrogen oxidation reaction (HOR) electrocatalysts are promising anode materials for the anion exchange membrane fuel cells (AEMFCs), but their application is hindered by their inherent instability fo...
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Open AccessDelineating the early dissemination mechanisms of acral melanoma by integrating single-cell and spatial transcriptomic analyses
Acral melanoma (AM) is a rare subtype of melanoma characterized by a high incidence of lymph node (LN) metastasis, a critical factor in tumor dissemination and therapeutic decision-making. Here, we employ sing...
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Open AccessCharacterization of two O-methyltransferases involved in the biosynthesis of O-methylated catechins in tea plant
Tea is known for having a high catechin content, with the main component being (−)-epigallocatechin gallate (EGCG), which has significant bioactivities, including potential anti-cancer and anti-inflammatory ac...
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Open AccessA unique van Hove singularity in kagome superconductor CsV3-xTaxSb5 with enhanced superconductivity
Van Hove singularity (VHS) has been considered as a driving source for unconventional superconductivity. A VHS in two-dimensional (2D) materials consists of a saddle point connecting electron-like and hole-lik...
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Open AccessCost-minimization analysis of oral versus intravenous antibiotic treatment for Klebsiella pneumoniae liver abscess
A cost-minimization analysis was conducted for Klebsiella pneumoniae liver abscess (KLA) patients enrolled in a randomized controlled trial which found oral ciprofloxacin to be non-inferior to intravenous (IV) ce...
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Open AccessThe impact of methicillin resistance on clinical outcome among patients with Staphylococcus aureus osteomyelitis: a retrospective cohort study of 482 cases
This study was designed to evaluate the impact of methicillin resistance on the outcomes among patients with S. aureus osteomyelitis. We reviewed all extremity osteomyelitis patients treated in our clinic center ...
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Open AccessIKKα inhibition re-sensitizes acquired adriamycin-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis
IKKα has been shown to be responsible of multiple pro-tumorigenic functions and therapy resistance independent of canonical NF-κB, but its role in acquired chemotherapy resistance in breast cancer remains uncl...
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Open AccessIntegrating terrestrial and aquatic ecosystems to constrain estimates of land-atmosphere carbon exchange
In this Perspective, we put forward an integrative framework to improve estimates of land-atmosphere carbon exchange based on the accumulation of carbon in the landscape as constrained by its lateral export th...
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Open AccessDiel variations in planktonic ciliate community structure in the northern South China Sea and tropical Western Pacific
Though diel variations are geographically widespread phenomena among phytoplankton and zooplankton, knowledge is limited regarding diel variations in planktonic ciliate (microzooplankton) community structure. ...
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Open AccessGSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis
Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we gene...
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Open AccessA molecular atlas reveals the tri-sectional spinning mechanism of spider dragline silk
The process of natural silk production in the spider major ampullate (Ma) gland endows dragline silk with extraordinary mechanical properties and the potential for biomimetic applications. However, the precise...
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Open AccessEGFR, HER2, and HER3 protein expression in paired primary tumor and lymph node metastasis of colorectal cancer
Due to the difficulty in sampling of metastatic tumors, patient selection is commonly based on results of primary tumor samples when metastatic samples are not available. However, due to tumor heterogeneity, m...
