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Article
Open AccessUltrastiff metamaterials generated through a multilayer strategy and topology optimization
Metamaterials composed of different geometrical primitives have different properties. Corresponding to the fundamental geometrical forms of line, plane, and surface, beam-, plate-, and shell-based lattice meta...
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Article
Open AccessHigh-strength and crack-free welding of 2024 aluminium alloy via Zr-core-Al-shell wire
The 2000 series aluminium alloys are qualified for widespread use in lightweight structures, but solidification cracking during fusion welding has been a long-standing issue. Here, we create a zirconium (Zr)-c...
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Article
Open AccessSolvent-pair surfactants enabled assembly of clusters and copolymers towards programmed mesoporous metal oxides
Organic-inorganic molecular assembly has led to numerous nano/mesostructured materials with fantastic properties, but it is dependent on and limited to the direct interaction between host organic structure-dir...
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Article
Open AccessEnantioselective synthesis of chiral quinohelicenes through sequential organocatalyzed Povarov reaction and oxidative aromatization
Heterohelicenes are of increasing importance in the fields of materials science, molecular recognition, and asymmetric catalysis. However, enantioselective construction of these molecules, especially by organo...
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Article
Open AccessDevelopment and validation of a nomogram for predicting Mycoplasma pneumoniae pneumonia in adults
The study aimed to explore predictors of Mycoplasma pneumoniae pneumonia (MPP) in adults and develop a nomogram predictive model in order to identify high-risk patients early. We retrospectively analysed the clin...
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Article
Open AccessWorsening hearing was associated with higher β-amyloid and tau burden in age-related hearing loss
Age-related hearing loss (ARHL) represents the frequently occurring disability that affects the elderly worldwide. The recent evidence has calculated ARHL to be most potential risk factor to predict dementia. ...
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Article
Open Access4210 Da and 1866 Da polypeptides as potential biomarkers of liver disease progression in hepatitis B virus patients
HBV infection is recognized as a serious global health problem, and hepatitis B virus infection is a complicated chronic disease leading to liver cirrhosis (LC) and hepatocellular carcinoma (HCC). New biochemi...
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Article
Open AccessEffect of sowing proportion on above- and below-ground competition in maize–soybean intercrops
The relative contribution of above- and below-ground competition to crop yield under intercrop** systems is critical to understanding the mechanisms of improved yield. Changes in the content of above- and be...
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Article
Open AccessSwitchable organoplatinum metallacycles with high quantum yields and tunable fluorescence wavelengths
The preparation of fluorescent discrete supramolecular coordination complexes (SCCs) has attracted considerable attention within the fields of supramolecular chemistry, materials science, and biological scienc...
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Article
Open AccessAuthor Correction: A Survival Metadata Analysis Responsive Tool (SMART) for web-based analysis of patient survival and risk
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessA global strategy to mitigate the environmental impact of China’s ruminant consumption boom
Rising demand for ruminant meat and dairy products in develo** countries is expected to double anthropogenic greenhouse gas and ammonia emissions from livestock by 2050. Mitigation strategies are urgently ne...
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Article
Open AccessThree-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells
Retinal organoids are three-dimensional structures derived from human pluripotent stem cells (hPSCs) which recapitulate the spatial and temporal differentiation of the retina, serving as effective in vitro models...
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Article
Open AccessA novel, non-invasive model for diagnosing liver fibrosis stage in patients with hepatocellular carcinoma
The aim of this study was to investigate the diagnostic value of the platelet count-to-spleen volume ratio (PSR) for diagnosing hepatic fibrosis in patients with hepatocellular carcinoma (HCC). In this interim...
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Article
Open AccessA Survival Metadata Analysis Responsive Tool (SMART) for web-based analysis of patient survival and risk
Health information systems contain extensive amounts of patient data. Information relevant to public health and individuals’ medical histories are both available. In clinical research, the prediction of patien...
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Article
Open AccessInhibition of the glutaredoxin and thioredoxin systems and ribonucleotide reductase by mutant p53-targeting compound APR-246
The tumor suppressor p53 is commonly inactivated in human tumors, allowing evasion of p53-dependent apoptosis and tumor progression. The small molecule APR-246 (PRIMA-1Met) can reactive mutant p53 in tumor cells ...
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Article
Open AccessSynergistic antibacterial activity of silver with antibiotics correlating with the upregulation of the ROS production
Thiol-dependent enzymes, including the thioredoxin (Trx) and glutathione (GSH) systems, have recently been found as promising bactericidal targets in multidrug-resistant (MDR) bacteria. We previously discovere...
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Article
Open AccessAssessing the ecosystem services provided by urban green spaces along urban center-edge gradients
Urban green spaces provide various ecosystem services, especially cultural services. Previous assessment methods depend either on hypothetic payments for ecosystems or real payments not directly related to eco...
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Article
Open AccessEnhancement of porcine intramuscular fat content by overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase in skeletal muscle
Intramuscular fat (IMF) content has been generally recognized as a desirable trait in pork meat because of its positive effect on eating quality. An effective approach to enhance IMF content in pork is the gen...
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Article
Metal-free porous nitrogen-doped carbon nanotubes for enhanced oxygen reduction and evolution reactions
Develo** efficient metal-free bi-functional electrocatalysts is required to reduce costs and improve the slow oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) kinetics in electrochemical s...
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Article
Open AccessEvidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptors
Acid-sensing ion channel 3 (ASIC3) is involved in acid nociception, but its possible role in neurosensory mechanotransduction is disputed. We report here the generation of Asic3-knockout/eGFPf-knockin mice and su...