52 Result(s)
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**yong Peng
Cell Biology
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Article
Open AccessThe marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes
Prostate cancer (PCa) ranks as the second most prevalent cancer in men, with advanced stages posing significant treatment challenges. Given its solid tumor nature, PCa is highly susceptible to hypoxia, a condi...
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Open AccessMacrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury
Damage to renal tubular epithelial cells (RTECs) signaled the onset and progression of sepsis-associated acute kidney injury (SA-AKI). Recent research on mitochondria has revealed that mitophagy plays a crucia...
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Hypothermic machine perfusion reduces donation after circulatory death liver ischemia–reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway
Hypothermic machine perfusion (HMP) has been demonstrated to be more effective in mitigating ischemia–reperfusion injury (IRI) of donation after circulatory death (DCD) organs than cold storage (CS), yet the u...
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Correction: ROR1-targeting switchable CAR-T cells for cancer therapy
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Transcription Factor TFAP2B Exerts Neuroprotective Effects Targeting BNIP3-Mediated Mitophagy in Ischemia/Reperfusion Injury
Cerebral ischemia–reperfusion injury (CIRI) leads to malignant brain edema, blood–brain barrier destruction, and neuronal apoptosis. N6-methyladenosine (m6A) RNA modification in CIRI was still limited explored...
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Open AccessmiR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired differentiation and uncontrolled proliferation of myeloid blasts. Tumor suppressor p53 is often downregulated in AML cel...
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TEAD4 predicts poor prognosis and transcriptionally targets PLAGL2 in serous ovarian cancer
The oncogenic function of TEA domain transcription factor 4 (TEAD4) has been confirmed in multiple human malignancies, while its potential role and regulatory mechanism in serous ovarian cancer progression are...
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Cloning and Functional Identification of Gibberellin Receptor SvGID1s Gene of Salix viminalis
Gibberellins (GAs) play a key role in the transition from vegetative growth to flowering and the GA receptor GID1 (GIBBERELLIN INSENSITIVE DWARF1) is the central part of GA-signaling. The differential expressi...
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circPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription
CircRNAs are a class of single-stranded molecules with tissue/development-specific expression patterns. Increasing evidence demonstrates that circRNAs play important roles in physiological or pathological cond...
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ROR1-targeting switchable CAR-T cells for cancer therapy
The success of chimeric antigen receptor T cell (CAR-T) therapy in the treatment of hematologic malignancies has prompted the development of numerous CAR-T technologies, including switchable CAR-T (sCAR-T) sys...
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Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways
Diabetes mellitus (DM) is a metabolic syndrome, caused by insufficient insulin secretion or insulin resistance (IR). DM enhances oxidative stress and induces mitochondrial function in different kinds of cell t...
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Knockdown of hsa_circ_0001964 inhibits hepatocellular carcinoma cell proliferation by inactivating PI3K/AKT signaling pathway
Circular RNAs (CircRNAs) play vital roles in the pathogenesis of hepatocellular carcinoma (HCC). However, the exact role and detailed mechanism of hsa_circ_0001964 during HCC carcinogenesis remains unknown.
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Open AccessDownregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI
Sepsis-induced AKI (acute kidney injury) is considered an inflammation-related disease with high mortality. LPS-induced (Lipopolysaccharide) TLR4-NFκB pathway activation plays an important role in sepsis-induc...
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Open AccessThe protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis
It is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently pericyte-derived microvesicles (PMVs) were confirmed to be therapeutic in many ...
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Open AccessCD73-positive extracellular vesicles promote glioblastoma immunosuppression by inhibiting T-cell clonal expansion
Extracellular vesicles are involved in the occurrence, progression and metastasis of glioblastoma (GBM). GBM can secrete a variety of tumour-derived extracellular vesicles (TDEVs) with high immunosuppressive a...
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Open AccessMitochondrial Drp1 recognizes and induces excessive mPTP opening after hypoxia through BAX-PiC and LRRK2-HK2
Mitochondrial mass imbalance is one of the key causes of cardiovascular dysfunction after hypoxia. The activation of dynamin-related protein 1 (Drp1), as well as its mitochondrial translocation, play important...
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Open AccessInhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis
Some individuals develop prediabetes and/or diabetes following acute pancreatitis (AP). AP-induced beta-cell injury and the limited regenerative capacity of beta cells might account for pancreatic endocrine in...
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Open AccessRetraction Note: Dioscin induces prostate cancer cell apoptosis through activation of estrogen receptor-β
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Open AccessRetraction Note: FABP4 contributes to renal interstitial fibrosis via mediating inflammation and lipid metabolism
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NK and NKT cells have distinct properties and functions in cancer
Natural killer (NK) and natural killer T (NKT) cells are two important cell subsets of the innate immune system. NK and NKT cells share many phenotypes and functions for anti-tumor immunity; however, the dynam...
