82 Result(s)
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**yong Peng
Life Sciences
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Article
Open AccessThe marine-derived HIF-1α inhibitor, Yardenone 2, reduces prostate cancer cell proliferation by targeting HIF-1 target genes
Prostate cancer (PCa) ranks as the second most prevalent cancer in men, with advanced stages posing significant treatment challenges. Given its solid tumor nature, PCa is highly susceptible to hypoxia, a condi...
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Open AccessMacrophage migration inhibitory factor (MIF) suppresses mitophagy through disturbing the protein interaction of PINK1-Parkin in sepsis-associated acute kidney injury
Damage to renal tubular epithelial cells (RTECs) signaled the onset and progression of sepsis-associated acute kidney injury (SA-AKI). Recent research on mitochondria has revealed that mitophagy plays a crucia...
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Hypothermic machine perfusion reduces donation after circulatory death liver ischemia–reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway
Hypothermic machine perfusion (HMP) has been demonstrated to be more effective in mitigating ischemia–reperfusion injury (IRI) of donation after circulatory death (DCD) organs than cold storage (CS), yet the u...
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Author Correction: m6A-SAC-seq for quantitative whole transcriptome m6A profiling
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Open AccessPannexin 1 targets mitophagy to mediate renal ischemia/reperfusion injury
Renal ischemia/reperfusion (I/R) injury contributes to the development of acute kidney injury (AKI). Kidney is the second organ rich in mitochondrial content next to the heart. Mitochondrial damage substantial...
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Open AccessmiR-221/222 induce instability of p53 By downregulating deubiquitinase YOD1 in acute myeloid leukemia
Acute myeloid leukemia (AML) is a hematological malignancy characterized by the impaired differentiation and uncontrolled proliferation of myeloid blasts. Tumor suppressor p53 is often downregulated in AML cel...
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Synergistic effect of elevated glucose levels with SARS-CoV-2 spike protein induced NOX-dependent ROS production in endothelial cells
Diabetic patients infected with coronavirus disease 2019 (COVID-19) often have a higher probability of organ failure and mortality. The potential cellular mechanisms through which blood glucose exacerbates tis...
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TEAD4 predicts poor prognosis and transcriptionally targets PLAGL2 in serous ovarian cancer
The oncogenic function of TEA domain transcription factor 4 (TEAD4) has been confirmed in multiple human malignancies, while its potential role and regulatory mechanism in serous ovarian cancer progression are...
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circPTPN14 promotes renal fibrosis through its interaction with FUBP1 to enhance MYC transcription
CircRNAs are a class of single-stranded molecules with tissue/development-specific expression patterns. Increasing evidence demonstrates that circRNAs play important roles in physiological or pathological cond...
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A tRF oligomerizes Nucleolin to stabilize metastasis-favoring transcripts
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m6A-SAC-seq for quantitative whole transcriptome m6A profiling
N6-methyladenosine (m6A) is the most abundant mRNA modification in mammalian cells, regulating many physiological processes. Here we describe a method for base-resolution, quantitative m6A sequencing in the whole...
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Author Correction: m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
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m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome
Functional studies of the RNA N6-methyladenosine (m6A) modification have been limited by an inability to map individual m6A-modified sites in whole transcriptomes. To enable such studies, here, we introduce m6A-s...
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Open AccessMacrophage-derived exosomal aminopeptidase N aggravates sepsis-induced acute lung injury by regulating necroptosis of lung epithelial cell
Sepsis-induced acute lung injury (ALI) is a serious sepsis complication and the prevailing cause of death. Circulating plasma exosomes might exert a key role in regulating intercellular communication between i...
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Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways
Diabetes mellitus (DM) is a metabolic syndrome, caused by insufficient insulin secretion or insulin resistance (IR). DM enhances oxidative stress and induces mitochondrial function in different kinds of cell t...
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Knockdown of hsa_circ_0001964 inhibits hepatocellular carcinoma cell proliferation by inactivating PI3K/AKT signaling pathway
Circular RNAs (CircRNAs) play vital roles in the pathogenesis of hepatocellular carcinoma (HCC). However, the exact role and detailed mechanism of hsa_circ_0001964 during HCC carcinogenesis remains unknown.
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Open AccessDownregulation of macrophage migration inhibitory factor attenuates NLRP3 inflammasome mediated pyroptosis in sepsis-induced AKI
Sepsis-induced AKI (acute kidney injury) is considered an inflammation-related disease with high mortality. LPS-induced (Lipopolysaccharide) TLR4-NFκB pathway activation plays an important role in sepsis-induc...
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Standard litterbags underestimate early-stage lower-order root decomposition rate in a subtropical forest, China
The standard litterbag method isolates soil or litter from decomposing roots by a dense nylon mesh that is likely to underestimate root decomposition rate. Thus, we evaluated the effect of direct contact betwe...
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Open AccessThe protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis
It is well known that sepsis is a prevalent severe disease caused by infection and the treatment strategies are limited. Recently pericyte-derived microvesicles (PMVs) were confirmed to be therapeutic in many ...
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Open AccessCD73-positive extracellular vesicles promote glioblastoma immunosuppression by inhibiting T-cell clonal expansion
Extracellular vesicles are involved in the occurrence, progression and metastasis of glioblastoma (GBM). GBM can secrete a variety of tumour-derived extracellular vesicles (TDEVs) with high immunosuppressive a...
