36 Result(s)

Article

LPS-induced monocarboxylate transporter-1 inhibition facilitates lactate accumulation triggering epithelial-mesenchymal transformation and pulmonary fibrosis

The epithelial-mesenchymal transformation (EMT) process of alveolar epithelial cells is recognized as involved in the development of pulmonary fibrosis. Recent evidence has shown that lipopolysaccharide (LPS)-...

**hua Feng, Han Zhong, Shuya Mei, Ri Tang… in Cellular and Molecular Life Sciences (2024)

Article

CPT-11 mitigates autoimmune diseases by suppressing effector T cells without affecting long-term anti-tumor immunity

The incidence of autoimmune diseases has significantly increased over the past 20 years. Excessive host immunoreactions and disordered immunoregulation are at the core of the pathogenesis of autoimmune disease...

Hantian Liang, **nzou Fan, Hao Cheng, **ao Ma, Yutong Sun, Fang Nan… in Cell Death Discovery (2024)

Article

Pyruvate kinase M2 regulates mitochondrial homeostasis in cisplatin-induced acute kidney injury

An important pathophysiological process of acute kidney injury (AKI) is mitochondrial fragmentation in renal tubular epithelial cells, which leads to cell death. Pyruvate kinase M2 (PKM2) is an active protein ...

Wenjia **e, Qingyun He, Yan Zhang, **nxin Xu, ** Wen, Hongdi Cao… in Cell Death & Disease (2023)

Article

The complete and fully-phased diploid genome of a male Han Chinese

Since the release of the complete human genome, the priority of human genomic study has now been shifting towards closing gaps in ethnic diversity. Here, we present a fully phased and well-annotated diploid hu...

Chentao Yang, Yang Zhou, Yanni Song, Dongya Wu, Yan Zeng, Lei Nie… in Cell Research (2023)

Article

Knockdown of Porf-2 restores visual function after optic nerve crush injury

Retinal ganglion cells (RGCs), the sole output neurons in the eyes, are vulnerable to diverse insults in many pathological conditions, which can lead to permanent vision dysfunction. However, the molecular and...

Di Chen, Yi-Yu Sun, Lai-Yang Zhou, Xu Han, Shuo Yang, Fei-Yang Hong… in Cell Death & Disease (2023)

Article

LSM14B controls oocyte mRNA storage and stability to ensure female fertility

Controlled mRNA storage and stability is essential for oocyte meiosis and early embryonic development. However, how to regulate mRNA storage and stability in mammalian oogenesis remains elusive. Here we showed...

Li-Ying Shan, Yu Tian, Wen-**ang Liu, Hai-Tao Fan… in Cellular and Molecular Life Sciences (2023)

Article

FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells

Female subfertility is an increasing reproductive issue worldwide, which is partially related to abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary physical support and ...

Chen Wang, Hui Sun, John S. Davis, **aojie Wang, Lijun Huo, Nan Sun… in Cell Death & Disease (2023)

Article

Elevated fatty acid β-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway

Fibroblast-like synoviocytes (FLS) maintain chronic inflammation leading to joint destruction in rheumatoid arthritis (RA). Fatty acid β-oxidation (FAO) regulates cell function. Here, we aimed to investigate t...

**g Wei, **nxin Huang, **ng Zhang, Guanghong Chen, Cheng Zhang… in Cell Death & Disease (2023)

Article

FcγRIIIA activation-mediated up-regulation of glycolysis alters MDSCs modulation in CD4⁺ T cell subsets of Sjögren syndrome

Our and other researchers’ previous studies found that myeloid-derived suppressor cells (MDSCs) were increased, and these MDSCs, supposed to play immunosuppressive roles, showed significant pro-inflammatory ef...

**g**g Qi, **nyang Zhou, Ziran Bai, Zhimin Lu, **aolu Zhu… in Cell Death & Disease (2023)

Article

Correction to: MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening

Guangsuo **ng, Zichao Liu, Luyuan Huang, Danyun Zhao… in Cell Death & Differentiation (2022)

Article

Cellular basis of enhanced humoral immunity to SARS-CoV-2 upon homologous or heterologous booster vaccination analyzed by single-cell immune profiling

SARS-CoV-2 vaccine booster dose can induce a robust humoral immune response, however, its cellular mechanisms remain elusive. Here, we investigated the durability of antibody responses and single-cell immune p...

**gwen Ai, **gxin Guo, Haocheng Zhang, Yi Zhang, Haochen Yang, Ke Lin… in Cell Discovery (2022)

Article

SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation

Increasing research has uncovered the involvement of long noncoding RNAs (lncRNAs) in the progression of multiple cancers including lung adenocarcinoma (LUAD). RT-qPCR and western blot were done to measure RNA...

Yuan Yuan, Danyang Zhou, Feifei Chen, Zhenhua Yang, Wei Gu… in Cell Death & Disease (2022)

Article

Loss of neurodevelopmental-associated miR-592 impairs neurogenesis and causes social interaction deficits

microRNA-592 (miR-592) has been linked to neurogenesis, but the influence of miR-592 knockout in vivo remains unknown. Here, we report that miR-592 knockout represses IPC-to-mature neuron transition, impairs m...

Yu Fu, Yang Zhou, Yuan-Lin Zhang, Bo Zhao, … in Cell Death & Disease (2022)

Article

Neuronal GRK2 regulates microglial activation and contributes to electroacupuncture analgesia on inflammatory pain in mice

G protein coupled receptor kinase 2 (GRK2) has been demonstrated to play a crucial role in the development of chronic pain. Acupuncture is an alternative therapy widely used for pain management. In this study,...

Yu Chen, Yang Zhou, **ao-Chen Li, Xue Ma, Wen-Li Mi, Yu-**a Chu… in Biological Research (2022)

Article

Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern

**gwen Ai, Haocheng Zhang, Qiran Zhang, Yi Zhang, Ke Lin, Zhangfan Fu… in Cell Research (2022)

Article

Upregulation of lncRNA NONRATG019935.2 suppresses the p53-mediated apoptosis of renal tubular epithelial cells in septic acute kidney injury

Although increasing evidence has confirmed that the apoptosis of renal tubular epithelial cells (RTECs) is a crucial contributor to the onset and development of septic acute kidney injury (AKI), the pathologic...

Ying Ding, Dao-yang Zhou, Hong Yu, Tao Zhu, Feng Guo, Yang He… in Cell Death & Disease (2021)

Article

Sirtuin 3 regulates mitochondrial protein acetylation and metabolism in tubular epithelial cells during renal fibrosis

Proximal tubular epithelial cells (TECs) demand high energy and rely on mitochondrial oxidative phosphorylation as the main energy source. However, this is disturbed in renal fibrosis. Acetylation is an import...

Yu Zhang, ** Wen, **g Luo, Hao Ding, Hongdi Cao, Weichun He… in Cell Death & Disease (2021)

Article

CPT1α maintains phenotype of tubules via mitochondrial respiration during kidney injury and repair

Impaired energy metabolism in proximal tubular epithelial cells (PTECs) is strongly associated with various kidney diseases. Here, we characterized proximal tubular phenotype alternations during kidney injury ...

Qi Yuan, Yunhui Lv, Hao Ding, Qingqing Ke, Caifeng Shi, **g Luo… in Cell Death & Disease (2021)