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Chapter
Implantation and Characterization of Human Breast Carcinomas in SCID Mice
To establish a better animal model for the study of human breast carcinomas, we investigated the growth and metastatic potential of surgical specimens of human breast carcinomas in SCID mice, using the large a...
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Protocol
Calcium Mobilization in Ovarian Cancer Cells in Response to Lysophospholipids
Intracellular free Ca2+concentration ([Ca2+]i) plays a critical role in regulating many diverse cellular functions including cell proliferation and programmed cell death (apoptosis) (1). An elevation in [Ca2+]i a...
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Article
Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon
In order to discover global gene expression patterns characterizing subgroups of colon cancer, microarrays were hybridized to labeled RNAs obtained from seventeen colonic specimens (nine carcinomas and eight n...
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Article
An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma
Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this reg...
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Article
A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin
Since preclinical studies have shown more than additive cytotoxicity and DNA damage with the combination of gemcitabine and 5-fluoro-2′-deoxyuridine (FUDR), we studied this combination in a phase I trial.
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Article
Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk
Patients with Barrett's esophagus (BE) are at increased risk of develo** esophageal adenocarcinoma (EAC). Clinical neoplastic progression risk factors, such as age and the length of the esophageal BE segment...
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Article
Phase III clinical trials of the cell differentiation agent-2 (CDA-2): Therapeutic efficacy on breast cancer, non-small cell lung cancer and primary hepatoma1
The objective of this study was to explore the effect of CDA-2, a selective inhibitor of abnormal methylation enzymes in cancer cells, on the therapeutic efficacy of cytotoxic chemotherapy.
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Article
KiSS1 Suppresses Metastasis in Human Ovarian Cancer via Inhibition of Protein Kinase C Alpha
Metastasis is a vital target for cancer treatment, since the majority of cancer patients die from metastatic, rather than the primary disease. KiSS1 has been identified as a metastasis suppressor gene in melanoma...
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Article
Expression of Collagen IV, Fibronectin, Laminin in Non-small Cell Lung Cancer and Its Correlation with Chemosensitivities and Apoptosis
Objective: To study the expression of extracellular matrix (ECM) proteins including Collagen IV (Co IV), Fibronectin, Laminin in human non-small cell lung cancer (NSCLC) specimens and the relationship between ...
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Article
Expressions and clinicopathologic significance of five heat shock proteins in esophageal squamous cell carcinoma
To investigate the expressions of heat shock protein (hsp) 10, hsp27, hsp60, hsp70 and hsp90α in esophageal squamous cell carcinoma (ESCC) and normal tissues along the incisal margin (TIM), and discuss the cli...
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Article
Clinical significance of heat shock protein 10 in large bowel carcinoma
To investigate the expression of heat shock protein 10 (HSP10) during genesis and development of large bowel carcinoma and discuss the clinical significance about its expression.
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Article
Expression of fascin in thyroid neoplasms: a novel diagnostic marker
Fascin, an actin-bundling protein, is markedly upregulated in several epithelial tumors and its expression often correlates with high-grade, extensive invasion, and distant metastasis. However, reports about f...
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Article
Open AccessThalidomide influences growth and vasculogenic mimicry channel formation in melanoma
To observe the effects of thalidomide on melanoma tumor growth and blood supply patterns in C57 mice.
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Article
Open AccessChemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer
To identify the roles of CXCL12 and CXCR4 and the associated mechanism involved in perineural invasion of prostate cancer.
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Article
Immunosuppressive activity of mesenchymal stem cells is not decreased in children with aplastic anemia
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Article
Open AccessExpression and prognostic significance of THBS1, Cyr61 and CTGF in esophageal squamous cell carcinoma
Thrombospondin1 (THBS1), cystene-rich protein 61 (Cyr61) and connective tissue growth factor (CTGF) are all involved in the transforming growth factor-beta (TGF-β) signal pathway, which plays an important role...
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Article
Prognostic Significance of Microscopic Positive Margins for Gastric Cancer Patients with Potentially Curative Resection
Most previous studies concerning the impact of positive margins on patient outcomes were based on patients with D1 lymphadenectomy. The prognostic significance of positive margins for patients with D2/D3 lymph...
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Article
A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women
RecQ helicases play a central role in maintaining genome stability and may interact with some important cancer-related proteins such as BRCA1. Mutations of the human RecQ helicase genes WRN and BLM lead to rare a...
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Chapter
Lipid Generation and Signaling in Ovarian Cancer
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Article
Open AccessDifferential expression of decorin, EGFR and cyclin D1 during mammary gland carcinogenesis in TA2 mice with spontaneous breast cancer
The Tientsin Albino 2 (TA2) mouse is an inbred strain originating from the Kunming strain. It has a high incidence of spontaneous breast cancer without the need for external inducers or carcinogens. Until now,...
